Chen C C, Hsin W C, Ko F N, Huang Y L, Ou J C, Teng C M
National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
J Nat Prod. 1996 Dec;59(12):1149-50. doi: 10.1021/np960443+.
Fractionation of the EtOH extract of Justicia procumbens, guided by antiplatelet bioassay, led to the isolation of nine known arylnaphthalide lignans, neojusticin A (1), justicidin B (2), justicidin A (3), taiwanin E methyl ether (4), neojusticin B (5), chinensinaphthol methyl ether (6), taiwanin E (8), chinensinaphthol (9), and diphyllin (10), and a new arylnaphthalide lignan that was characterized by spectral means as 4'-demethylchinensinaphthol methyl ether (7). Compounds 1, 2, 4, and 8 significantly inhibited platelet aggregation.
在抗血小板生物测定的指导下，对爵床乙醇提取物进行分级分离，得到了9种已知的芳基萘内酯木脂素，新爵床素A（1）、爵床素B（2）、爵床素A（3）、台湾脂素E甲醚（4）、新爵床素B（5）、中华脂素萘酚甲醚（6）、台湾脂素E（8）、中华脂素萘酚（9）和双叶豆素（10），以及一种新的芳基萘内酯木脂素，通过光谱手段将其鉴定为4'-去甲基中华脂素萘酚甲醚（7）。化合物1、2、4和8显著抑制血小板聚集。
