用二磺化铝酞菁和5-氨基酮戊酸诱导的原卟啉IX对犬前列腺进行间质光动力治疗。
Interstitial photodynamic therapy in the canine prostate with disulfonated aluminum phthalocyanine and 5-aminolevulinic acid-induced protoporphyrin IX.
作者信息
Chang S C, Buonaccorsi G A, MacRobert A J, Bown S G
机构信息
Department of Surgery, University College London Medical School, UK.
出版信息
Prostate. 1997 Jul 1;32(2):89-98. doi: 10.1002/(sici)1097-0045(19970701)32:2<89::aid-pros3>3.0.co;2-a.
BACKGROUND
Photodynamic therapy (PDT) is an experimental approach for treating prostate cancer localized to the gland that does not involve surgery or irradiation. Second-generation photosensitizers 5-aminolevulinic acid (ALA) and aluminum disulfonated phthalocyanine (AlS2Pc) were studied in the normal canine prostate.
METHODS
Tissue biodistribution of photosensitizers on serial biopsies was examined using fluorescence microscopy. Photodynamic therapy was done by delivering red light interstitially at 100 mW through fibers placed under transrectal ultrasound guidance.
RESULTS
Peak levels of AlS2Pc appeared at 5-24 hr and at 3 hr for ALA. Macroscopic PDT lesions were up to 12 mm in diameter using AlS2Pc, but only 1-2 mm with ALA. Light at 300 mW caused thermal lesions. At 28 days, damaged glands remained atrophic, but the interlobular supporting stroma was well-preserved. Urethral lesions healed by 28 days without functional impairment.
CONCLUSIONS
Although the results with ALA were disappointing, PDT using AlS2Pc looks like a promising modality for treatment of localized prostate cancer.
背景
光动力疗法（PDT）是一种用于治疗局限于前列腺腺体的癌症的实验性方法，不涉及手术或放疗。在正常犬前列腺中研究了第二代光敏剂5-氨基乙酰丙酸（ALA）和二磺酸铝酞菁（AlS2Pc）。
方法
使用荧光显微镜检查连续活检组织中光敏剂的组织生物分布。通过经直肠超声引导下放置的光纤以100 mW的功率间隙性地输送红光来进行光动力疗法。
结果
AlS2Pc的峰值水平出现在5 - 24小时，而ALA的峰值水平出现在3小时。使用AlS2Pc时，宏观光动力疗法病变直径可达12毫米，而使用ALA时仅为1 - 2毫米。300 mW的光会导致热损伤。在28天时，受损腺体仍萎缩，但小叶间支持基质保存良好。尿道病变在28天时愈合，无功能障碍。
结论
尽管ALA的结果令人失望，但使用AlS2Pc的光动力疗法看起来是治疗局限性前列腺癌的一种有前景的方法。
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