Damgaard P H, Granum P E, Bresciani J, Torregrossa M V, Eilenberg J, Valentino L
Department of Ecology and Molecular Biology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
FEMS Immunol Med Microbiol. 1997 May;18(1):47-53. doi: 10.1111/j.1574-695X.1997.tb01026.x.
Four strains of Bacillus thuringiensis were isolated from infections in burn wounds and from water used in the treatment of burn wounds. The strains produced large parasporal inclusion bodies composed of 141, 83, and 81 kDa protoxins. The four strains were tested for insecticidal activity against larvae of Pieris brassicae and Aedes aegypti but showed no activity; Vero cell assays for the production of enterotoxins were also negative. Attempts to classify the strains according to flagellar H-serotype showed them all to be non-flagellated. Apart from two occupational health accidents that occurred during the handling of highly concentrated B. thuringiensis fluids, this is the first report of B. thuringiensis causing non-gastrointestinal clinical infection in immunosuppressed patients.
从烧伤创面感染以及用于治疗烧伤创面的水中分离出了4株苏云金芽孢杆菌。这些菌株产生了由141 kDa、83 kDa和81 kDa原毒素组成的大型伴孢晶体。对这4株菌株针对粉纹夜蛾和埃及伊蚊幼虫的杀虫活性进行了测试，但未显示出活性；针对产肠毒素的Vero细胞检测也呈阴性。根据鞭毛H血清型对这些菌株进行分类的尝试表明它们均无鞭毛。除了在处理高浓度苏云金芽孢杆菌液时发生的两起职业健康事故外，这是关于苏云金芽孢杆菌在免疫抑制患者中引起非胃肠道临床感染的首次报告。
