Lebwohl M, Hecker D, Martinez J, Sapadin A, Patel B
Department of Dermatology, Mount Sinai School of Medicine, New York 10029-6574, USA.
J Am Acad Dermatol. 1997 Jul;37(1):93-5. doi: 10.1016/s0190-9622(97)70217-2.
Calcipotriene is often used with UVB or PUVA, but interactions between UV radiation and calcipotriene have not been examined extensively.
Our purpose was to examine interactions between calcipotriene and UV light.
Minimal erythema doses (MEDs) were determined with UVB and immediate pigment darkening was measured for UVA. The effect of calcipotriene ointment applied before phototesting was examined. Thick and thin applications of calcipotrience were compared. Calcipotriene ointment was applied to a small area on the skin before phototherapy. Patients received either UVB, PUVA, UVA, or no phototherapy. After phototherapy, the ointment was collected and assayed by reverse-phase, high-performance liquid chromatography.
MEDs for UVB and immediate pigment darkening for UVA were unaffected by calcipotriene. Thick application of calcipotriene, however, increased the MED, UVA caused substantial reductions in the concentration of detectable calcipotriene.
When used in conjunction with PUVA, calcipotriene should be applied after exposure to UVA.
卡泊三醇常用于联合中波紫外线（UVB）或补骨脂素加紫外线A（PUVA）治疗，但紫外线辐射与卡泊三醇之间的相互作用尚未得到广泛研究。
我们的目的是研究卡泊三醇与紫外线之间的相互作用。
用UVB测定最小红斑量（MED），用UVA测量即时色素沉着。研究了光试验前涂抹卡泊三醇软膏的效果。比较了卡泊三醇的厚涂和薄涂。在光疗前将卡泊三醇软膏涂抹于皮肤的小面积区域。患者接受UVB、PUVA、UVA或不进行光疗。光疗后，收集软膏并通过反相高效液相色谱法进行测定。
UVB的MED和UVA的即时色素沉着不受卡泊三醇影响。然而，卡泊三醇的厚涂增加了MED，UVA导致可检测到的卡泊三醇浓度大幅降低。
与PUVA联合使用时，卡泊三醇应在暴露于UVA后涂抹。
