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海洋硅藻中肋骨条藻（Skeletonema costatum (Grev.) Cleve.）的有机提取物对非小细胞支气管肺癌细胞系（NSCLC-N6）的抗增殖作用。

Antiproliferative effects of an organic extract from the marine diatom Skeletonema costatum (Grev.) Cleve. Against a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).

作者信息

Bergé J P, Bourgougnon N, Carbonnelle D, Le Bert V, Tomasoni C, Durand P, Roussakis C

机构信息

Laboratoire de Biochimie et Molécules Marines IFREMER, Nantes, France.

出版信息

Anticancer Res. 1997 May-Jun;17(3C):2115-20.

PMID:9216673
Abstract

An organic extract of the marine diatom Skeletonema costatum was studied in vitro for its effect on asynchronous cells of a human non-small-cell bronchoplumanory carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events are related to a terminal maturation induction.

摘要

对海洋硅藻中肋骨条藻的有机提取物进行了体外研究，以观察其对人非小细胞支气管肺癌细胞系（NSCLC-N6）的异步细胞的影响。细胞生长似乎在细胞周期的G1期受到抑制，对预处理细胞的动力学研究表明，这种生长停滞是不可逆的。这些事件与终末成熟诱导有关。

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