George J R, Fitchen J H
Epitope, Inc., Beaverton, Oregon 97008-7108, USA.
Am J Med. 1997 Apr 1;102(4A):21-5. doi: 10.1016/s0002-9343(97)00034-x.
Research has demonstrated that oral mucosal transudate (OMT), a serum-derived fluid that enters saliva from the gingival crevice and across oral mucosal surfaces, can be preferentially concentrated by a novel collecting system to yield detectable levels of immunoglobulins (i.e., IgG and IgM antibodies) against various bacterial and viral diseases. Assays based on OMT can aid in the diagnosis of disease and in the management of therapeutic drugs. A reliable and accurate OMT-based test to detect human immunodeficiency virus (HIV) antibodies is commercially available. Additional tests based on similar technologies may aid in the diagnosis of viral hepatitis, measles, mumps, and rubella as well as in monitoring levels of therapeutic drugs such as theophylline. The future use of OMT-based testing will likely increase because of the inherent advantages of this technology: convenience; avoidance of inadvertent transmission of blood-borne pathogens; ease of use in pediatric and geriatric populations; as well as the potential for blood-free home and workplace collection of patient samples.
研究表明，口腔黏膜渗出液（OMT）是一种从牙龈沟进入唾液并穿过口腔黏膜表面的血清源性液体，一种新型收集系统可以优先对其进行浓缩，以产生可检测水平的针对各种细菌和病毒疾病的免疫球蛋白（即IgG和IgM抗体）。基于OMT的检测可有助于疾病诊断和治疗药物管理。一种基于OMT检测人类免疫缺陷病毒（HIV）抗体的可靠且准确的检测方法已在市场上有售。基于类似技术的其他检测可能有助于诊断病毒性肝炎、麻疹、腮腺炎和风疹，以及监测诸如茶碱等治疗药物的水平。由于该技术的固有优势，基于OMT检测的未来应用可能会增加：方便；避免血源性病原体的意外传播；便于在儿科和老年人群中使用；以及有可能在家庭和工作场所无血采集患者样本。
