Yagi H, Tokura Y, Matsushita K, Hanaoka K, Furukawa F, Takigawa M
Department of Dermatology, Hamamatsu University School of Medicine, Japan.
Br J Dermatol. 1997 Jun;136(6):918-23.
Wells' syndrome, or eosinophilic cellulitis, is a rare dermatosis characterized histologically by a dermal infiltrate of eosinophils, lymphocytes and histiocytes between collagen bundles and amorphous or granular eosinophilic deposits on collagen, constituting flame figures. We report a 54-year-old woman with eosinophilic cellulitis whose peripheral blood showed a marked eosinophilia and a high proportion of CD4+CD7- cells before treatment. Reverse transcriptase-polymerase chain reaction revealed that CD4+CD7- cells, but neither CD4+CD7+ nor CD4-CD8+ cells, in the circulating mononuclear cells expressed mRNA for interleukin (IL)-5, the major cytokine involved in eosinophilia. The proportion of CD4+CD7- cells decreased, and expression of mRNA for IL-5 disappeared in the peripheral blood, when the disease was treated by the administration of intravenous recombinant interferon-gamma. These findings suggest that circulating CD4+CD7- T cells play a pivotal role in the pathogenesis of eosinophilic cellulitis by producing IL-5.
韦尔斯综合征，即嗜酸性粒细胞性蜂窝织炎，是一种罕见的皮肤病，组织学特征为胶原束之间有嗜酸性粒细胞、淋巴细胞和组织细胞浸润，以及胶原上出现无定形或颗粒状嗜酸性沉积物，形成火焰状图形。我们报告一名54岁嗜酸性粒细胞性蜂窝织炎女性患者，其治疗前外周血显示明显的嗜酸性粒细胞增多和高比例的CD4+CD7-细胞。逆转录聚合酶链反应显示，循环单核细胞中的CD4+CD7-细胞而非CD4+CD7+或CD4-CD8+细胞表达白细胞介素（IL）-5的信使核糖核酸，IL-5是参与嗜酸性粒细胞增多的主要细胞因子。当通过静脉注射重组干扰素-γ治疗该疾病时，外周血中CD4+CD7-细胞的比例下降，IL-5信使核糖核酸的表达消失。这些发现表明，循环中的CD4+CD7- T细胞通过产生IL-5在嗜酸性粒细胞性蜂窝织炎的发病机制中起关键作用。
