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黑热病后皮肤利什曼病

Post-kala-azar dermal leishmaniasis.

作者信息

Girgla H S, Marsden R A, Singh G M, Ryan T J

出版信息

Br J Dermatol. 1977 Sep;97(3):307-11. doi: 10.1111/j.1365-2133.1977.tb15188.x.

DOI:10.1111/j.1365-2133.1977.tb15188.x
PMID:921902
Abstract

Ten patients with post-kala-azar dermal leishmaniasis (2 females, 8 males-aged 17-47 years) are described. Two of them had macular lesions in which very few Leishman-Donovan bodies were seen and who responded well to treatment with stibophen. Five patients had both macular and nodular lesions, Leishman-Donovan bodies being present in nodules but not in macules. Treatment with stibophen caused partial regression of nodules. Nodular lesions were found in three patients, who did not have macules. They contained numerous Leishman-Donovan bodies and treatment produced only temporary improvement. The variable response to treatment with stibophen may have been due to differences in parasitic load. The difficulty in distinguishing this disease from leprosy is discussed.

摘要

本文描述了10例黑热病后皮肤利什曼病患者(2例女性,8例男性,年龄在17至47岁之间)。其中2例有斑疹病变,仅见极少量利什曼 - 多诺万小体,用锑波芬治疗效果良好。5例既有斑疹又有结节性病变,结节中有利什曼 - 多诺万小体,斑疹中则没有。锑波芬治疗使结节部分消退。3例患者仅有结节性病变,无斑疹。结节中含有大量利什曼 - 多诺万小体,治疗仅产生暂时改善。对锑波芬治疗的不同反应可能是由于寄生虫负荷的差异。文中还讨论了将这种疾病与麻风病区分开来的困难。

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Post-kala-azar dermal leishmaniasis.黑热病后皮肤利什曼病
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引用本文的文献

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Indian Dermatol Online J. 2018 Jan-Feb;9(1):78-79. doi: 10.4103/idoj.IDOJ_49_17.
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Post-kala-azar dermal leishmaniasis in the Indian subcontinent: A threat to the South-East Asia Region Kala-azar Elimination Programme.印度次大陆的黑热病后皮肤利什曼病:对东南亚区域消除黑热病规划的一个威胁
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Cutaneous Manifestations of Human and Murine Leishmaniasis.
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Int J Mol Sci. 2017 Jun 18;18(6):1296. doi: 10.3390/ijms18061296.
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Leishmania promastigote membrane antigen-based enzyme-linked immunosorbent assay and immunoblotting for differential diagnosis of Indian post-kala-azar dermal leishmaniasis.基于利什曼原虫前鞭毛体膜抗原的酶联免疫吸附测定和免疫印迹法用于印度黑热病后皮肤利什曼病的鉴别诊断
J Clin Microbiol. 2005 Mar;43(3):1269-77. doi: 10.1128/JCM.43.3.1269-1277.2005.