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Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis.

作者信息

Jira W, Spiteller G, Richter A

机构信息

Lehrstuhl für Organische Chemie I, Universität Bayreuth, NW I, Germany.

出版信息

Chem Phys Lipids. 1997 May 30;87(1):81-9. doi: 10.1016/s0009-3084(97)00030-3.

DOI:10.1016/s0009-3084(97)00030-3
PMID:9219348
Abstract

9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from rheumatoid arthritis for a factor of 20-50 compared to healthy individuals of the same age. Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1 beta. The latter induces bone degression. The genesis of 9- and 13-HODE seems therefore to be an important factor in the development and progression of rheuma; in addition 9-HODE was reported to be a stimulus of inflammation, comparable to leukotrienes.

摘要

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