Kane C J, Sims T J, Gilmore S A
Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Brain Res. 1997 Jun 6;759(1):163-5. doi: 10.1016/s0006-8993(97)00359-4.
Aging in the brain is associated with specific changes in the astrocyte population. The present study establishes that similar changes occur in the aging spinal cord. The levels of glial fibrillary acidic protein (GFAP) mRNA were significantly increased 0.4-fold in aged 8- to 17-month-old rats compared to young 2-month-old rats. The ability of astrocytes in the aging spinal cord to respond to a non-invasive CNS injury was compared to young rats 4 days following sciatic nerve axotomy. The level of GFAP mRNA was significantly increased 0.5-fold in the young rats in response to axotomy. In contrast, the level of GFAP mRNA in aged rats did not increase following injury above that present in non-axotomized rats of the same age.
大脑衰老与星形胶质细胞群体的特定变化有关。本研究证实，衰老的脊髓中也会发生类似变化。与2个月大的年轻大鼠相比，8至17个月大的老年大鼠中胶质纤维酸性蛋白（GFAP）mRNA水平显著升高了0.4倍。在坐骨神经切断术后4天，将衰老脊髓中星形胶质细胞对非侵入性中枢神经系统损伤的反应能力与年轻大鼠进行比较。年轻大鼠在轴突切断术后GFAP mRNA水平显著升高了0.5倍。相比之下，老年大鼠受伤后GFAP mRNA水平并未高于同龄未进行轴突切断的大鼠。
