Gilmore S A, Kane C J
Department of Anatomy-510, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.
Brain Res. 1998 Sep 21;806(1):113-6. doi: 10.1016/s0006-8993(98)00754-9.
Peripheral nerve axotomy activates microglia and astrocytes within regions of brainstem or spinal cord from which the nerve arises. The present study demonstrates that unilateral sciatic axotomy in rats 2 to 18 months of age results in differing responses with age between these two glial populations. By 4 days postaxotomy, both astrocytes and microglia become activated in 2-month-old rats, whereas only the microglial population shows evidence of activation in rats 8 to 18 months of age.
外周神经切断术会激活神经发出部位的脑干或脊髓区域内的小胶质细胞和星形胶质细胞。本研究表明，2至18月龄大鼠的单侧坐骨神经切断术会导致这两种神经胶质细胞群的反应随年龄不同而有所差异。在切断神经后4天，2月龄大鼠的星形胶质细胞和小胶质细胞均被激活，而在8至18月龄大鼠中，只有小胶质细胞群显示出激活的迹象。
