Hahn E C, Page G R, Hahn P S, Gillis K D, Romero C, Annelli J A, Gibbs E P
Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign 61801, USA.
Vet Microbiol. 1997 Apr;55(1-4):123-30. doi: 10.1016/s0378-1135(96)01309-0.
To understand the possible mechanisms of transmission of Aujeszky's disease virus (pseudorabies or PRV) from a feral pig reservoir, intranasal infections were initiated in domestic pigs and in pigs from a herd derived from captured feral pigs. Virus strains originating from feral pigs and from domestic pigs were compared. Similar shedding patterns were obtained in both feral-derived and domestic pigs, however, virus strains from feral pigs were markedly attenuated. Virus could be isolated after acute infection from nasal secretions, tonsils and occasionally from genital organs. In studies of transmission of PRV by cannibalism, either latently infected or acutely infected tissue was fed to both domestic and feral-derived pigs. In two similar experiments, latently infected tissue did not transmit virus, but tissues from acutely infected pigs did transmit infection. Cannibalism was observed typically in both types of pigs older than 6 weeks of age. It was concluded that transmission of PRV originating from feral pigs can occur by several mechanisms including the respiratory route and by cannibalism of pigs that die of acute infection. Transmission of PRV from feral swine may, however, result in sub-clinical infection.
为了解奥耶斯基氏病病毒（伪狂犬病或PRV）从野猪宿主传播的可能机制，对家猪和来自捕获野猪群体的猪进行了鼻内感染。比较了源自野猪和家猪的病毒株。在源自野猪和家猪的猪中获得了相似的排毒模式，然而，源自野猪的病毒株明显减毒。急性感染后可从鼻分泌物、扁桃体，偶尔从生殖器官中分离出病毒。在通过同类相食传播PRV的研究中，将潜伏感染或急性感染的组织喂给家猪和源自野猪的猪。在两项类似实验中，潜伏感染的组织未传播病毒，但急性感染猪的组织确实传播了感染。同类相食通常在6周龄以上的两种猪中观察到。得出的结论是，源自野猪的PRV可通过多种机制传播，包括呼吸道途径和对死于急性感染的猪的同类相食。然而，PRV从野猪的传播可能导致亚临床感染。
