阿托品对大鼠离体全胃中乙酰胆碱、组胺和胃泌素刺激的胃酸分泌的影响。
The effect of atropine on acid secretion stimulated by acetylcholine, histamine and gastrin in the isolated whole stomach of the rat.
作者信息
Bunce K T, Marsh G F, Parsons M E
出版信息
Br J Pharmacol. 1977 Oct;61(2):279-84. doi: 10.1111/j.1476-5381.1977.tb08416.x.
Abstract
1 An isolated stomach preparation from immature rats has been used to study the effect of atropine on gastric acid secretion. 2 The acid secretory response to acetylcholine was not inhibited by atropine at a concentration of 0.3 micrometer. Concentrations of atropine of 1 to 3 micrometer produced a measurable inhibition of acid secretion, and a concentration of atropine of 10 micrometer caused a complete block of acid secretion which could not be surmounted by high concentrations of acetylcholine. 3 The acid secretory response to histamine was not inhibited by concentrations of atropine of up to 1 mM. 4 Concentrations of atropine of 1 micrometer and 10 micrometer did not inhibit gastrin-stimulated acid secretion, although a significant inhibition of acid output was observed with atropine at concentrations of 0.1 mM and 1 mM. 5 These findings are discussed in relation to the role of cholinergic mechanisms in the control of gastric acid secretion.
摘要
- 已使用未成熟大鼠的离体胃制备物来研究阿托品对胃酸分泌的影响。2. 浓度为0.3微米的阿托品未抑制对乙酰胆碱的酸分泌反应。浓度为1至3微米的阿托品对酸分泌产生了可测量的抑制作用，而浓度为10微米的阿托品导致酸分泌完全受阻，高浓度的乙酰胆碱无法克服这种阻碍。3. 浓度高达1毫摩尔的阿托品未抑制对组胺的酸分泌反应。4. 浓度为1微米和10微米的阿托品未抑制胃泌素刺激的酸分泌，尽管在浓度为0.1毫摩尔和1毫摩尔的阿托品作用下观察到酸分泌量有显著抑制。5. 结合胆碱能机制在胃酸分泌控制中的作用对这些发现进行了讨论。
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