Yanushpolsky E H, Politch J A, Hill J A, Anderson D J
Department of Obstetrics, Gynecology, and Reproductive Biology, Fearing Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Fertil Steril. 1995 Jan;63(1):142-7.
To determine the efficacy of common antibiotic therapies for treatment of leukocytospermia of unknown etiology.
Prospective, randomized, controlled clinical study.
Fertility and Endocrinology Unit at Brigham and Women's Hospital, Boston, Massachusetts.
One thousand seven hundred ten male partners in infertile couples attending the Fertility and Endocrinology Unit.
Concentrations of seminal peroxidase-positive granulocytes were determined during all routine semen analyses performed over a 30-month period. Of 119 men found to have leukocytospermia (> 10(6) granulocytes/mL semen) on first visit, 54 agreed to be randomized into one of three groups, and 41 patients completed the study. Group I (n = 13) and their wives received a 14-day course of oral doxycycline, 100 mg twice per day. Group II (n = 11) and their wives received a 14-day course of oral trimethoprim 160 mg-sulfamethoxazole 800 mg twice per day. Group III (n = 17) and their wives received no therapy. Four weeks after randomization, repeat semen analyses and granulocyte quantitations were done.
Neither of the antibiotic regimens resulted in a significantly higher rate of resolution of leukocytospermia over that seen in the control group.
There is a high rate of spontaneous resolution of leukocytospermia after one positive test. Antibiotics are no more beneficial than no therapy for treatment of this condition.
确定常见抗生素疗法治疗病因不明的白细胞精子症的疗效。
前瞻性、随机、对照临床研究。
马萨诸塞州波士顿布里格姆妇女医院生殖与内分泌科。
1710名在生殖与内分泌科就诊的不育夫妇中的男性伴侣。
在30个月内进行的所有常规精液分析中测定精液中过氧化物酶阳性粒细胞的浓度。在首次就诊时发现119名男性患有白细胞精子症（精液中粒细胞>10⁶/mL），其中54人同意随机分为三组，41名患者完成了研究。第一组（n = 13）及其妻子接受为期14天的口服强力霉素治疗，每天两次，每次100 mg。第二组（n = 11）及其妻子接受为期14天的口服甲氧苄啶160 mg - 磺胺甲恶唑800 mg治疗，每天两次。第三组（n = 17）及其妻子不接受治疗。随机分组四周后，进行重复精液分析和粒细胞定量。
两种抗生素治疗方案在白细胞精子症缓解率方面均未显著高于对照组。
一次检测呈阳性后，白细胞精子症的自发缓解率很高。抗生素治疗此病并不比不治疗更有益。
