黑腹果蝇超氧化物歧化酶基因座的DNA变异：自然选择的一个不断展开的故事。
DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection.
作者信息
Hudson R R, Sáez A G, Ayala F J
机构信息
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7725-9. doi: 10.1073/pnas.94.15.7725.
Abstract
Patterns of variation at the Sod locus of Drosophila melanogaster suggest that the protein polymorphism at this locus has very recently arisen. In addition, it appears that a previously rare DNA variant has been recently and rapidly driven to intermediate frequency. From the size of the region (>20 kb) that has been swept along with this rare variant, and patterns of linkage disequilibrium in the region, it is inferred that strength of selection was large (s > 0.01) and that the sweep occurred more than 25,000 generations ago. In addition, there are striking similarities to patterns of variation observed at the Est6 and Est-P loci, which are located approximately 1,000 kb from Sod.
摘要
黑腹果蝇Sod基因座的变异模式表明，该基因座的蛋白质多态性是最近才出现的。此外，一个先前罕见的DNA变体似乎最近迅速达到了中等频率。从与这个罕见变体一起被扫描的区域大小（>20 kb）以及该区域的连锁不平衡模式可以推断，选择强度很大（s > 0.01），并且这种扫描发生在25000代以前。此外，它与在Est6和Est-P基因座观察到的变异模式有显著相似之处，这两个基因座距离Sod约1000 kb。
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本文引用的文献
1
Inversions fail to account for allozyme clines.倒位无法解释同工酶梯度。
Genetics. 1978 Mar;88(3):515-27. doi: 10.1093/genetics/88.3.515.
2
Genetic Differentiation between Geographically Distant Populations of DROSOPHILA MELANOGASTER.地理上相隔的黑腹果蝇种群的遗传分化。
Genetics. 1982 Jun;101(2):235-56. doi: 10.1093/genetics/101.2.235.
3
Is esterase-P encoded by a cryptic pseudogene in Drosophila melanogaster?酯酶-P是由黑腹果蝇中的一个隐蔽假基因编码的吗？
Genetics. 1996 Dec;144(4):1511-8. doi: 10.1093/genetics/144.4.1511.
4
Nucleotide polymorphism in the 5' promoter region of esterase 6 in Drosophila melanogaster and its relationship to enzyme activity variation.黑腹果蝇酯酶6基因5'启动子区域的核苷酸多态性及其与酶活性变异的关系。
Genetics. 1995 Sep;141(1):215-22. doi: 10.1093/genetics/141.1.215.
5
The effect of superoxide dismutase alleles on aging in Drosophila.超氧化物歧化酶等位基因对果蝇衰老的影响。
Genetica. 1993;91(1-3):143-9. doi: 10.1007/BF01435994.
6
Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster.黑腹果蝇超氧化物歧化酶（Sod）区域正选择的证据。
Genetics. 1994 Apr;136(4):1329-40. doi: 10.1093/genetics/136.4.1329.
7
Superoxide dismutase in Drosophila melanogaster: biochemical and structural characterization of allozyme variants.黑腹果蝇中的超氧化物歧化酶：同工酶变体的生化与结构特征
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7052-5. doi: 10.1073/pnas.78.11.7052.
8
Superoxide dismutase in Drosophila melanogaster. Mutation site difference between two electromorphs.黑腹果蝇中的超氧化物歧化酶。两种电泳变体之间的突变位点差异。
FEBS Lett. 1985 Jan 1;179(1):115-9. doi: 10.1016/0014-5793(85)80203-9.
9
Linkage disequilibrium in natural and experimental populations of Drosophila melanogaster.黑腹果蝇自然种群和实验种群中的连锁不平衡。
Genetics. 1988 Dec;120(4):1043-51. doi: 10.1093/genetics/120.4.1043.
10
The coalescent process in models with selection and recombination.具有选择和重组的模型中的合并过程。
Genetics. 1988 Nov;120(3):831-40. doi: 10.1093/genetics/120.3.831.
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