泰氏蝎毒素诱导大鼠脑皮质突触体释放三磷酸腺苷

Tityustoxin-induced release of ATP from rat brain cortical synaptosomes.

作者信息

Salgado A H, Prado M A, Moraes-Santos T, Romano-Silva M A, Gomez M V

机构信息

Departamento de Fisiologia e Biofisica, Faculdade de Farmácia, -UFMG, Minas Gerais, Brazil.

出版信息

Neurosci Lett. 1997 Jun 27;229(2):113-6. doi: 10.1016/s0304-3940(97)00436-9.

DOI:10.1016/s0304-3940(97)00436-9

PMID:9223604

Abstract

Tityustoxin, a scorpion toxin that alters the Na+ channel activity, induces release of ATP from rat brain cortical synaptosomes. The effect of tityustoxin is dependent on its concentration and incubation time. Continuously or cumulative release of ATP evoked by tityustoxin was calcium-dependent and interestingly only partially inhibited by tetrodotoxin. We suggest that tityustoxin mainly releases ATP from the vesicular pool but other pools may also be involved.

摘要

替尤斯毒素是一种能改变钠离子通道活性的蝎毒素，可诱导大鼠脑皮质突触体释放三磷酸腺苷（ATP）。替尤斯毒素的作用取决于其浓度和孵育时间。替尤斯毒素诱发的ATP持续释放或累积释放依赖于钙离子，且有趣的是，仅部分受河豚毒素抑制。我们认为，替尤斯毒素主要从囊泡池释放ATP，但其他池也可能参与其中。