Tityustoxin-induced release of ATP from rat brain cortical synaptosomes.
作者信息
Salgado A H, Prado M A, Moraes-Santos T, Romano-Silva M A, Gomez M V
机构信息
Departamento de Fisiologia e Biofisica, Faculdade de Farmácia, -UFMG, Minas Gerais, Brazil.
出版信息
Neurosci Lett. 1997 Jun 27;229(2):113-6. doi: 10.1016/s0304-3940(97)00436-9.
PMID:9223604
Abstract
Tityustoxin, a scorpion toxin that alters the Na+ channel activity, induces release of ATP from rat brain cortical synaptosomes. The effect of tityustoxin is dependent on its concentration and incubation time. Continuously or cumulative release of ATP evoked by tityustoxin was calcium-dependent and interestingly only partially inhibited by tetrodotoxin. We suggest that tityustoxin mainly releases ATP from the vesicular pool but other pools may also be involved.
摘要
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