Henriques M C, Gomez M V
Brain Res Bull. 1981 Sep;7(3):255-9. doi: 10.1016/0361-9230(81)90016-2.
The effect of tityustoxin on calcium uptake in synaptosomes incubated in hypotonic medium low sodium and physiological medium high sodium was studied. In the hypotonic medium, calcium uptake was ATP and temperature dependent and TsTX inhibits this uptake. The inhibition of calcium uptake was not due to an osmotic effect since it was also observed in conditions of physiological cell osmolarity. In the physiological medium high sodium, tityustoxin stimulated calcium uptake in synaptosomes. The effect was inhibited by tetrodotoxin and cocaine. The stimulating effect of tityustoxin was specific for sodium concentration in the medium and neither choline nor sucrose could substitute sodium in its activation of the stimulation of calcium uptake in synaptosomes by tityustoxin.
研究了南美毒蛛毒素对在低渗低钠培养基和生理高钠培养基中孵育的突触体摄取钙的影响。在低渗培养基中，钙摄取依赖于ATP和温度，并且南美毒蛛毒素抑制这种摄取。钙摄取的抑制并非由于渗透效应，因为在生理细胞渗透压条件下也观察到了这种抑制。在生理高钠培养基中，南美毒蛛毒素刺激突触体摄取钙。该效应被河豚毒素和可卡因抑制。南美毒蛛毒素的刺激效应对于培养基中的钠浓度具有特异性，胆碱和蔗糖均不能替代钠来激活南美毒蛛毒素对突触体摄取钙的刺激作用。
