Collazo C M, Galán J E
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, 11794-5222, USA.
Gene. 1997 Jun 11;192(1):51-9. doi: 10.1016/s0378-1119(96)00825-6.
The genetic determinants that confer upon Salmonella the ability to enter non-phagocytic cells are largely encoded in a pathogenicity island located at centisome 63 of the bacterial chromosome. Molecular genetic analysis has revealed that this region encodes a specialized protein secretion system that mediates the export and/or translocation of putative signaling proteins into the host cell. This protein secretion system, which has been termed type III or contact-dependent, has also been identified in other plant and animal pathogens that have, in common, the ability to interact with eukaryotic host cells in an intimate manner.
赋予沙门氏菌进入非吞噬细胞能力的遗传决定因素，很大程度上由位于细菌染色体63分摩处的一个致病岛编码。分子遗传学分析表明，该区域编码一种特殊的蛋白质分泌系统，该系统介导假定的信号蛋白输出和/或转运到宿主细胞中。这种蛋白质分泌系统，被称为III型或接触依赖性系统，在其他植物和动物病原体中也已被鉴定出来，这些病原体的共同特点是能够与真核宿主细胞进行密切相互作用。
