Galán J E
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook 11794-5222, USA.
Mol Microbiol. 1996 Apr;20(2):263-71. doi: 10.1111/j.1365-2958.1996.tb02615.x.
Salmonella spp. can enter into non-phagocytic cells, a property that is essential for their pathogenicity. Recently, considerable progress has been made in the understanding of the molecular genetic bases of this process. It is now evident that Salmonella entry functions are largely encoded on a 35-40 kb region of the Salmonella chromosome located at centisome 63. The majority of the loci in this region encode components of a type III or contact-dependent secretion system homologous to those described in a variety of animal and plant-pathogenic bacteria as well as a number of proteins that require this system for their export to the extracellular environment. A somewhat unexpected finding has been the remarkable homology between the Salmonella and Shigella proteins that mediate the entry of these organisms into cultured epithelial cells.
沙门氏菌属能够侵入非吞噬细胞，这一特性对其致病性至关重要。最近，在理解这一过程的分子遗传基础方面取得了相当大的进展。现在很明显，沙门氏菌的侵入功能主要由位于染色体63分摩处的沙门氏菌染色体上一个35 - 40 kb的区域编码。该区域的大多数基因座编码III型或接触依赖性分泌系统的组分，这些组分与多种动物和植物病原菌中描述的组分同源，以及许多需要该系统才能输出到细胞外环境的蛋白质。一个有点意外的发现是，介导这些细菌进入培养上皮细胞的沙门氏菌和志贺氏菌蛋白质之间存在显著的同源性。
