Nakamura K, Hashimoto S, Honma S, Honma K, Tagawa Y
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
Psychiatry Clin Neurosci. 1997 Jun;51(3):115-9. doi: 10.1111/j.1440-1819.1997.tb02372.x.
Twenty-four-hour profiles of plasma melatonin, cortisol and rectal temperature were measured longitudinally in a sighted man who has been suffering from sleep disorders for more than 10 years. The sleep-wake rhythm of this subject free-ran, despite his routine life, and occasionally showed a sign of internal desynchronization, where sleep was lengthened up to 30 h. These states were classified into the non-24-hour sleep-wake syndrome. Plasma melatonin concentrations in the subjective night remained at a low level and showed a damped circadian rhythm. At the same time, robust circadian rhythms were detected in plasma cortisol and rectal temperature, indicating that the circadian pacemaker was intact. The causal relationship between the damping of nocturnal melatonin rise and a failure of entrainment of the sleep-wake cycle is discussed.
对一名患有睡眠障碍超过10年的视力正常男性进行了纵向的24小时血浆褪黑素、皮质醇和直肠温度监测。尽管该受试者生活规律，但他的睡眠-觉醒节律自由运转，偶尔表现出内部不同步的迹象，睡眠时间延长至30小时。这些状态被归类为非24小时睡眠-觉醒综合征。主观夜间的血浆褪黑素浓度维持在低水平，并呈现出衰减的昼夜节律。与此同时，在血浆皮质醇和直肠温度中检测到强烈的昼夜节律，表明昼夜节律起搏器完好无损。本文讨论了夜间褪黑素升高的衰减与睡眠-觉醒周期同步失败之间的因果关系。
