Benjamin S P, Mercer R D, Hawk W A
Cancer. 1977 Nov;40(5):2343-52. doi: 10.1002/1097-0142(197711)40:5<2343::aid-cncr2820400551>3.0.co;2-l.
Subcutaneous nodules from a newborn boy with "multiple fibromatosis" involving the head, neck, trunk, and all four extremities were studied by light microscopy, transmission electron microscopy, and immunofluorescent techniques. Light microscopy suggested a hamartomatous process with fibroblastic adipose, vasoformative and apparent smooth muscle components. The principal cell population combined ultrastructural characteristics of both fibroblasts and smooth muscle cells. Immunofluorescent studies revealed binding of human anti-smooth muscle antibody to the cytoplasm of the spindle cell population of the subdermal nodules but not to fibroblasts of the overlying un-involved skin. The ultrastructural and immunofluorescent studies revealed the previously underscribed fact that fibrous hamartoma of infancy is principally a proliferation of myofibroblasts. At age 8 months, there was complete spontaneous regression of all subcutaneous nodules not previously altered by excisional biopsy. The authors conclude that myofibroblasts are fibrocontractile cells, which play a role in shrinkage and eventual disappearance of these subdermal hamartomas.
对一名患有累及头部、颈部、躯干和四肢的“多发性纤维瘤病”的男婴的皮下结节进行了光镜、透射电镜和免疫荧光技术研究。光镜显示为一种错构瘤样病变，伴有成纤维细胞、脂肪、血管形成及明显的平滑肌成分。主要细胞群兼具成纤维细胞和平滑肌细胞的超微结构特征。免疫荧光研究显示，人抗平滑肌抗体与皮下结节梭形细胞群的细胞质结合，但不与上方未受累皮肤的成纤维细胞结合。超微结构和免疫荧光研究揭示了一个此前未描述的事实，即婴儿纤维性错构瘤主要是肌成纤维细胞的增殖。在8个月大时，所有未经切除活检改变的皮下结节完全自发消退。作者得出结论，肌成纤维细胞是纤维收缩细胞，在这些皮下错构瘤的收缩及最终消失中起作用。
