亚硝胺和亚硝酰胺在胃肠道癌症病因学中的作用
Nitrosamines and nitrosamides in the etiology of gastrointestinal cancer.
作者信息
Lijinsky W
出版信息
Cancer. 1977 Nov;40(5 Suppl):2446-9. doi: 10.1002/1097-0142(197711)40:5+<2446::aid-cncr2820400909>3.0.co;2-q.
Abstract
It has been amply demonstrated that N-nitroso compounds are formed by interaction of nitrite with secondary and tertiary amino compounds, and that this reaction can occur in vivo as well as in food processed with nitrite. The favored site of reaction in vivo is the stomach. It is likely that N-nitroso compounds formed in this way, especially nitrosamides, could reach the colon and contribute to the induction of colon tumors.
摘要
大量研究表明，亚硝酸盐与仲胺和叔胺化合物相互作用会形成N-亚硝基化合物，而且这种反应在体内以及用亚硝酸盐加工的食品中都可能发生。体内反应的主要部位是胃。以这种方式形成的N-亚硝基化合物，尤其是亚硝酰胺，很可能会到达结肠并促使结肠肿瘤的发生。
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