Cooper D M, Swanson D L, Barns S M, Gebhart C J
Division of Comparative Medicine, Research Animal Resources, Medical School, University of Minnesota, Minneapolis 55455, USA.
Int J Syst Bacteriol. 1997 Jul;47(3):635-9. doi: 10.1099/00207713-47-3-635.
Proliferative enteritis is an enteric disease that affects a variety of animals. The causative agent in swine has been determined to be an obligate intracellular bacterium, Lawsonia intracellularis, related to the sulfate-reducing bacterium Desulfovibrio desulfuricans. The intracellular agents found in the lesions of different animal species are antigenically similar. In addition, strains from the pig, ferret, and hamster have been shown to be genetically similar. In this study we performed a partial 16S ribosomal DNA sequence analysis on the intracellular agent of proliferative enteritis from a hamster, a deer, and an ostrich and compared these sequences to that of the porcine L. intracellularis isolate. Results of this study indicate that the intracellular agents from these species with proliferative enteritis have high sequence similarity, indicating that they are all in the genus Lawsonia and that they may also be the same species, L. intracellularis.
增生性肠炎是一种影响多种动物的肠道疾病。已确定猪的病原体是一种专性细胞内细菌——胞内劳森菌，它与硫酸盐还原菌脱硫脱硫弧菌有关。在不同动物物种病变中发现的细胞内病原体在抗原性上相似。此外，来自猪、雪貂和仓鼠的菌株已被证明在基因上相似。在本研究中，我们对来自仓鼠、鹿和鸵鸟的增生性肠炎细胞内病原体进行了部分16S核糖体DNA序列分析，并将这些序列与猪源胞内劳森菌分离株的序列进行了比较。本研究结果表明，这些患有增生性肠炎物种的细胞内病原体具有高度的序列相似性，表明它们都属于劳森菌属，并且它们可能也是同一物种——胞内劳森菌。
