Fountain S, Holland M K, Hinds L A, Janssens P A, Kerr P J
Cooperative Research Centre for Biological Control of Vertebrate Pest Populations, CSIRO Division of Wildlife and Ecology, Lyneham, Australia.
J Reprod Fertil. 1997 May;110(1):161-9. doi: 10.1530/jrf.0.1100161.
The pathogenesis of infertility associated with acute viral orchitis was investigated in a rabbit model. Infection of postpubertal male European rabbits with an attenuated strain of myxoma virus caused systemic disease with viral replication to high titres in the testes. Infected rabbits developed an interstitial orchitis and epididymitis. This was associated with degeneration of the seminiferous epithelium, decreased serum testosterone concentrations and increased serum LH concentrations. Virus was localized within the interstitial cells. Clearance of infectious virus from the testis occurred between day 20 and day 30 after infection, although viral DNA could still be detected by polymerase chain reaction at 120 days. Viral clearance was associated with a return to normal serum testosterone and LH concentrations. Anti-sperm antibodies were present in the serum as early as 5 days after infection and declined during the recovery phase. Rabbits were infertile at 60 days but returned to normal fertility 60-90 days after infection.
在兔模型中研究了与急性病毒性睾丸炎相关的不育症发病机制。用减毒黏液瘤病毒株感染青春期后的雄性欧洲兔，引发全身性疾病，病毒在睾丸中大量复制。受感染的兔子出现间质性睾丸炎和附睾炎。这与生精上皮变性、血清睾酮浓度降低和血清促黄体生成素浓度升高有关。病毒定位于间质细胞内。感染后第20天至第30天，睾丸中的传染性病毒被清除，尽管在120天时仍可通过聚合酶链反应检测到病毒DNA。病毒清除与血清睾酮和促黄体生成素浓度恢复正常有关。感染后5天血清中就出现了抗精子抗体，并在恢复阶段下降。兔子在60天时不育，但感染后60 - 90天恢复正常生育能力。
