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[重症医学中的伦理]

[Ethics in intensive medicine].

作者信息

List W F

机构信息

Univ. Klinik für Anästhesiologie und Intensivmedizin, K.F. Universität Graz, Osterreich.

出版信息

Anaesthesist. 1997 Apr;46(4):261-6. doi: 10.1007/s001010050399.

DOI:10.1007/s001010050399
PMID:9229978
Abstract

In more than 30 years of development of intensive care medicine (ICM), our specialty has acquired moral and ethical standpoints, although not without public pressure and discussions. Special commissions dealing, e.g., with brain death, terminal care, ethics of foregoing life-sustaining treatment in the critically ill, withholding or withdrawing mechanical ventilation, and other issues have been formed in a number of medical societies. International consensus conferences have helped to clarify some of the issues. With increasing experience, a multitude of ethical problems have arisen in ICM that have to be dealt with, such as the issue of quality of life. What is an unworthy life? Are we allowed to make judgments for our patients? What is cost-effectiveness in ICM? Other restrictions include bed and equipment shortages in the intensive care unit (ICU), the necessity for triage--undisputed in catastrophe medicine--and how one should proceed in managing elective patients? In situations of limited ICU bed availability, sicker patients will be admitted, sparing out patients who are less ill for observation and those with poor quality of life and poor prognosis. For the future, it will likely be necessary to define the patients who should be admitted to an ICU more than those who should not be admitted. An ICU treatment entitlement index would be directly proportional to the probability of successful outcome and the quality of the remaining life, and would be inversely related to costs for achieving success. The ICU outcome with survival, hospital mortality, and follow-up of ICU patients is considered. DNR (do not resuscitate), the dying patient, terminal care, terminal weaning--DNT (do not treat)--active and passive euthanasia, living wills, quality of life, and cost-effectiveness for ICU patients are defined. Their application in the ICU will be discussed and problems pointed out. Outcome predictions using scores (APACHE III, SAPS II, MPM) have been developed based on previous experience, but should only be applied to patient groups and for quality assurance in ICUs. The most frequent and difficult problem in the ICUs is the vegetative state, which requires an exact diagnosis. The differential diagnosis from other comatose states such as coma, brain death, and locked-in-syndrome is depicted. The ethics of interrupting life-sustaining treatment in critically ill patients have been worked out by a Task Force on Ethics of the Society of Critical Care Medicine (1990). A consensus was found that the patient may judge to forego therapy; ethically it is then appropriate to withhold or withdraw therapy. According to the consensus, withdrawing an already initiated treatment should not necessarily be regarded as more problematic than a decision not to initiate treatment. In my mind, however, there is a great difference between withdrawing or withholding, e.g., ventilation. A dissentive opinion by some members of the Task Force stated that hydration and nutrition other than high-technology or parenteral nutrition are key components of patient care, and should not be equated with medical intervention. The ethical problems associated with active euthanasia (physician-assisted suicide or death) as practised in the Netherlands are also discussed. In most countries this practice seems unacceptable. From 30 years experience in ICM, there are many more ethical questions and case reports without clear solutions. Care decisions for single patients in unacceptable situations should be made after medical evaluation by the intensivist with the medical team and, if possible, by the patient and/or his or her surrogate. Legislation and solutions cannot be expected for single patients, but ethics committees could be helpful in decision-making.

摘要

在重症监护医学(ICM)30多年的发展历程中,我们这个专业领域已经确立了道德和伦理立场,尽管这并非没有受到公众压力和引发诸多讨论。许多医学协会已经成立了专门委员会,比如处理脑死亡、临终关怀、重症患者放弃维持生命治疗的伦理问题、停止或撤销机械通气以及其他相关问题的委员会。国际共识会议有助于厘清其中一些问题。随着经验的不断积累,ICM中出现了众多必须加以应对的伦理问题,比如生活质量问题。什么样的生命是没有价值的?我们是否有权为患者做出判断?ICM中的成本效益是怎样的?其他限制因素包括重症监护病房(ICU)床位和设备短缺、分诊的必要性(这在灾难医学中是无可争议的)以及在处理择期患者时应如何操作?在ICU床位有限的情况下,病情较重的患者会被收治,而病情较轻的患者则被留出进行观察,以及那些生活质量差且预后不良的患者。对于未来而言,可能有必要更多地界定哪些患者应该被收治入ICU,而不是哪些患者不应该被收治。一个ICU治疗资格指数将与成功治疗结果的概率和剩余生命的质量成正比,而与实现成功治疗的成本成反比。同时还会考虑ICU患者的存活结局、医院死亡率以及随访情况。定义了“不要复苏”(DNR)、临终患者、临终关怀、临终撤机——“不要治疗”(DNT)——主动和被动安乐死、生前预嘱、生活质量以及ICU患者的成本效益等概念。将讨论它们在ICU中的应用并指出相关问题。基于以往经验开发了使用评分系统(APACHE III、SAPS II、MPM)进行结局预测,但这些评分系统仅应适用于患者群体以及用于ICU的质量保证。ICU中最常见且棘手的问题是植物人状态,这需要精确诊断。文中描述了与其他昏迷状态如昏迷、脑死亡和闭锁综合征的鉴别诊断。重症监护医学协会伦理特别工作组(1990年)已经制定了关于中断重症患者维持生命治疗的伦理准则。达成的共识是患者可以判断是否放弃治疗;从伦理角度来看,此时停止或撤销治疗是合适的。根据该共识,撤销已经开始的治疗不一定比决定不开始治疗更具问题。然而,在我看来,比如停止或不进行通气之间存在很大差异。特别工作组的一些成员持有不同意见,他们指出除高科技或肠外营养之外的水化和营养是患者护理的关键组成部分,不应等同于医疗干预。文中还讨论了荷兰实施的主动安乐死(医生协助自杀或死亡)所涉及的伦理问题。在大多数国家,这种做法似乎是不可接受的。从ICM 30年的经验来看,存在更多没有明确解决方案的伦理问题和病例报告。对于处于不可接受情况的单个患者的护理决策,应由重症监护医生与医疗团队进行医学评估后做出,如果可能的话,还应与患者和/或其代理人共同做出。对于单个患者而言,无法期待有立法和解决方案,但伦理委员会在决策过程中可能会有所帮助。

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引用本文的文献

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[Chronic critical disease--what does the long-term patient imply for intensive medicine].[慢性危重病——长期患者对重症医学意味着什么]
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本文引用的文献

1
Changing patterns of terminal care management in an intensive care unit.重症监护病房终末护理管理模式的转变
Crit Care Med. 1994 Feb;22(2):233-43. doi: 10.1097/00003246-199402000-00013.
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After Quinlan: the dilemma of the persistent vegetative state.昆兰事件之后:持续性植物状态的困境
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Identification of futility in intensive care.重症监护中无效性的识别。
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Regulating physician-assisted death.规范医生协助下的死亡。
N Engl J Med. 1994 Jul 14;331(2):119-23. doi: 10.1056/NEJM199407143310211.
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