Gokal R, Harding P, Turner R C
Clin Endocrinol (Oxf). 1977 Oct;7(4):301-5. doi: 10.1111/j.1365-2265.1977.tb01329.x.
Diurnal plasma insulin and glucose concentrations were studied in six diabetic patients, each treated with five different insulin regimes. Subcutaneous soluble insulin was too slow and long acting for physiological replacement of the normal insulin response to meals, but the peak insulin levels were higher than the postprandial levels of normal subjects. Intramuscular insulin, though absorbed more quickly than subcutaneous insulin, was not clinically advantageous. Three rather than two injections of soluble insulin gave improved blood glucose control but two combined injections of short and medium acting insulins gave nearly as good results. A long acting insulin was needed to prevent raised plasma glucose levels overnight.
对6名糖尿病患者进行了日间血浆胰岛素和葡萄糖浓度的研究，每名患者采用5种不同的胰岛素治疗方案。皮下注射可溶性胰岛素对于生理性替代正常的餐时胰岛素反应来说太慢且作用时间太长，但胰岛素峰值水平高于正常受试者的餐后水平。肌内注射胰岛素虽然比皮下注射胰岛素吸收更快，但在临床上并无优势。注射三次而非两次可溶性胰岛素可改善血糖控制，但两次联合注射短效和中效胰岛素也能取得几乎同样好的效果。需要一种长效胰岛素来防止夜间血浆葡萄糖水平升高。
