Williams M L, Savage D C
Arch Dis Child. 1979 Apr;54(4):295-8. doi: 10.1136/adc.54.4.295.
Total glycosylated haemoglobin (HbA1) levels were measured in 94 diabetic children aged between 3 and 19 years. The results were compared with traditional methods of assessing blood glucose control. HbA1 levels correlated with home urine glucose testing (P less than 0.05), with 24-hour urine glucose excretion (P less than 0.01), and with height velocity (P less than 0.001). Within the first two of these parameters there was a wide scatter of results, suggesting the inaccuracy of these methods for assessing control. The association of raised HbA1 levels with height velocities less than 10th centile shows the effect of poor control on growth. HbA1 may prove to be an objective method for assessing long-term blood glucose levels in diabetes, and thus it may be possible to determine the effect of good control in the prevention of the various diabetic complications.
对94名年龄在3至19岁之间的糖尿病儿童测量了糖化血红蛋白（HbA1）的总水平。将结果与评估血糖控制的传统方法进行了比较。HbA1水平与家庭尿糖检测相关（P<0.05），与24小时尿糖排泄相关（P<0.01），与身高增长速度相关（P<0.001）。在前两个参数中，结果存在广泛的离散，表明这些方法在评估控制方面不准确。HbA1水平升高与身高增长速度低于第10百分位数相关，这表明控制不佳对生长的影响。HbA1可能被证明是评估糖尿病患者长期血糖水平的一种客观方法，因此有可能确定良好控制在预防各种糖尿病并发症方面的效果。
