Homo-Delarche F
CNRS URA 1461, Université Paris V, Hôpital Necker, France.
Diabetes Metab. 1997 Jun;23(3):181-94.
beta-Cell function in non-insulin dependent diabetes mellitus (NIDDM) or type II diabetes, in particular during the prediabetic stage, has been more extensively investigated than in insulin-dependent diabetes mellitus (IDDM) or type I diabetes. Recently, however, the existence of a beta-cell dysfunction, early during the prediabetic stage of IDDM, and its possible contribution to the amplification of the autoimmune reaction have been underlined. Here, in a first of two parts, an attempt is made to review the various ways normal beta cells cope with increased demands on their resources in different models of hyperglycaemia in order to better delineate and compare the mechanisms implicating beta cells in the pathogenesis of both types of diabetes.
与胰岛素依赖型糖尿病（IDDM，即I型糖尿病）相比，非胰岛素依赖型糖尿病（NIDDM，即II型糖尿病），尤其是在糖尿病前期阶段，β细胞功能得到了更广泛的研究。然而，近来有观点强调，在IDDM糖尿病前期阶段早期存在β细胞功能障碍，并且其可能对自身免疫反应的放大有一定作用。本文分为两部分，此处为第一部分，旨在综述正常β细胞在不同高血糖模型中应对资源需求增加的各种方式，以便更好地描述和比较两种类型糖尿病发病机制中涉及β细胞的机制。
