Blancou J, Aubert M F
l'Office international des épizooties, Paris.
Bull Acad Natl Med. 1997 Feb;181(2):301-11; discussion 311-2.
The authors describe experimental inoculations of different animal species with either the wild-type rabies virus or the modified one through in vivo or in vitro passages. With these experiments, it was possible to determine the 50% lethal dose of these viruses for these species, and to thus quantify the importance of the species barrier that opposes, in particular, the transmission of vulpine rabies to cats and dogs (respectively 10(5) and 10(6) times more resistant than foxes). Studies were also undertaken on the influence of the inoculation route and that of serial passages of the virus in vivo or in vitro on the importance of resistance to rabies. The epidemiological consequences of the existence of a species barrier, its nature and variability, are discussed.
作者描述了通过体内或体外传代，用野生型狂犬病病毒或改良型狂犬病病毒对不同动物物种进行实验性接种。通过这些实验，可以确定这些病毒对这些物种的50%致死剂量，从而量化物种屏障的重要性，特别是该屏障对狐狸狂犬病向猫和狗传播的阻碍作用（猫和狗的抵抗力分别比狐狸高10^5和10^6倍）。还研究了接种途径以及病毒在体内或体外连续传代对接种狂犬病抵抗力的影响。文中讨论了物种屏障存在的流行病学后果、其性质和变异性。
