维拉帕米对肠道钙转运的影响。
The effect of verapamil on intestinal calcium transport.
作者信息
Wróbel J, Michalska L
出版信息
Eur J Pharmacol. 1977 Oct 15;45(4):385-7. doi: 10.1016/0014-2999(77)90279-5.
PMID:923648
Abstract
Verapamil (1.5 mM) completely inhibits active calcium transport by everted rat duodenum sacs and depresses oxygen consumption by duodenal rings. Increasing the Ca2+ concentration in the incubation medium from 0.4 mM 5.0 mM reverses the inhibition of oxygen consumption by verapamil but is without effect on the extent of inhibition of calcium active transport.
摘要
维拉帕米（1.5毫摩尔）完全抑制外翻大鼠十二指肠囊泡的主动钙转运，并降低十二指肠环的耗氧量。将孵育培养基中的钙离子浓度从0.4毫摩尔提高到5.0毫摩尔可逆转维拉帕米对耗氧量的抑制作用，但对钙主动转运的抑制程度没有影响。
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