Korpela R, Moilanen E, Saxelin M, Vapaatalo H
Institute of Biomedicine, Department of Pharmacology and Toxicology, Helsinki, Finland.
Int J Food Microbiol. 1997 Jun 17;37(1):83-6. doi: 10.1016/s0168-1605(97)00049-4.
Lactobacillus rhamnosus GG is an experimentally and clinically well documented probiotic used in different dairy products. The present study aimed to investigate the safety aspects of Lactobacillus rhamnosus GG, particularly with respect to platelet aggregation, the initiating event in thrombosis. Platelet rich plasma was separated from the blood of healthy volunteers, and the effects of Lactobacillus rhamnosus GG (ATCC 53103), Lactobacillus rhamnosus (ATCC 7469) and Enterococcus faecium T2L6 in different dilutions on spontaneous, ADP- and adrenaline-induced aggregation were tested. The bacteria did not influence spontaneous aggregation. Only Enterococcus faecium T2L6 enhanced the adrenaline-induced aggregation, with a less clear effect on ADP-induced aggregation.
鼠李糖乳杆菌GG是一种在实验和临床方面都有充分记录的益生菌，用于不同的乳制品中。本研究旨在调查鼠李糖乳杆菌GG的安全性，特别是关于血小板聚集这一血栓形成的起始事件。从健康志愿者的血液中分离出富含血小板的血浆，并测试了不同稀释度的鼠李糖乳杆菌GG（ATCC 53103）、鼠李糖乳杆菌（ATCC 7469）和粪肠球菌T2L6对自发性、ADP诱导和肾上腺素诱导的聚集的影响。这些细菌不影响自发性聚集。只有粪肠球菌T2L6增强了肾上腺素诱导的聚集，对ADP诱导的聚集的影响不太明显。
