脂肪酸掺入脑内的体内成像，以检查涉及磷脂的信号转导和神经可塑性。
In vivo imaging of fatty acid incorporation into brain to examine signal transduction and neuroplasticity involving phospholipids.
作者信息
Rapoport S I, Purdon D, Shetty H U, Grange E, Smith Q, Jones C, Chang M C
机构信息
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Ann N Y Acad Sci. 1997 May 30;820:56-73; discussion 73-4. doi: 10.1111/j.1749-6632.1997.tb46189.x.
An in vivo method is presented that allows quantification and imaging of fatty acid incorporation into different brain phospholipids in relation to membrane synthesis, neuroplasticity, and signal transduction. The method can be used with positron emission tomography, and may help to evaluate brain phospholipid metabolism in humans with brain tumors, neurodegenerative disease, cerebral ischemia or trauma, or neurotoxic effects of drugs or other agents.
本文介绍了一种体内方法，该方法能够对脂肪酸掺入不同脑磷脂的情况进行定量和成像，这与膜合成、神经可塑性和信号转导相关。该方法可用于正电子发射断层扫描，可能有助于评估患有脑肿瘤、神经退行性疾病、脑缺血或创伤的人类的脑磷脂代谢，或药物或其他制剂的神经毒性作用。
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