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[富含铁和抗坏血酸的奶粉作为基层医疗保健机构中治疗儿童缺铁性贫血的干预措施]

[Powdered milk enriched with iron and ascorbic acid as an intervention measure for treating iron deficiency anemia in children seen at a Basic Health Care Unit].

作者信息

Torres M A, Sato K, Juliano Y, Queiroz S de S

机构信息

Centro de Referência de Sańde, da Mulher, Nutrição, Alimentação e Desenvolvimento Infantil.

出版信息

Arch Latinoam Nutr. 1996 Jun;46(2):113-7.

PMID:9239287
Abstract

This study was undertaken to verify the influence of the use of iron and Vitamin C fortified powdered whole milk on the hemoglobin levels of 238 children, aged 6 to 18 months, seen at a Basic Health Care Unit in the State of São Paulo. The powdered milk was fortified with 9 mg of iron (ferrous sulfate) and 65 mg of Vitamin C for each 100 g of powder. 4 kg/month were distributed to children under one year and 2 kg/month to those over one year of age. Clinical, anthropometric and hematological (hemoglobin level measurements) evaluations were performed at the onset of the study and at three month intervals after the beginning of the supplementation. At the end of the trial, there was still enough milk available to extend the intervention for a group of 39 children who had presented the worst evolution in the first six months. At the onset of the study, 72.6% of the children presented anemia. After 3 and 6 months, these percentages had decreased to 38.9% and 18.5%, respectively. Among the children that were followed-up for 9 months, their were only 2.5% who presented anemia at the end of the intervention. The highest prevalences were found in the 6 to 12 months age group and the best results in the 10 to 18 month group. There was intrafamilial dilution of the milk in 30.7% of the cases. With or without intrafamilial milk sharing, there were significant decreases in anemia occurrences with no differences between the two groups. The use of fortified milk did not affect the children nutritional condition. This study permitted the conclusion that the fortification of foodstuffs, besides being the method of election for the prevention of iron deficiency, is an excellent alternative for the treatment of and recovery from iron deficient anemia in children under two years of age.

摘要

本研究旨在验证使用铁和维生素C强化的全脂奶粉对圣保罗州一家基层医疗单位收治的238名6至18个月大儿童血红蛋白水平的影响。每100克奶粉中添加了9毫克铁(硫酸亚铁)和65毫克维生素C。一岁以下儿童每月分发4千克,一岁以上儿童每月分发2千克。在研究开始时以及补充开始后的三个月间隔进行临床、人体测量和血液学(血红蛋白水平测量)评估。试验结束时,仍有足够的牛奶可用于对在前六个月中情况最差的39名儿童延长干预。研究开始时,72.6%的儿童患有贫血。3个月和6个月后,这些百分比分别降至38.9%和18.5%。在接受9个月随访的儿童中,干预结束时只有2.5%的儿童患有贫血。患病率最高的是6至12个月年龄组,而10至18个月组的效果最佳。30.7%的案例中存在家庭内奶粉稀释情况。无论是否存在家庭内奶粉共享,贫血发生率均显著下降,两组之间无差异。强化奶粉的使用未影响儿童的营养状况。本研究得出结论,食品强化除了是预防缺铁的首选方法外,还是治疗两岁以下儿童缺铁性贫血并使其康复的极佳选择。

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[Powdered milk enriched with iron and ascorbic acid as an intervention measure for treating iron deficiency anemia in children seen at a Basic Health Care Unit].[富含铁和抗坏血酸的奶粉作为基层医疗保健机构中治疗儿童缺铁性贫血的干预措施]
Arch Latinoam Nutr. 1996 Jun;46(2):113-7.
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[The effect of the use of milk fortified with iron and vitamin C on hemoglobin levels and nutritional status of children under 2].[使用铁和维生素C强化牛奶对2岁以下儿童血红蛋白水平和营养状况的影响]
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Effectiveness of fortification of drinking water with iron and vitamin C in the reduction of anemia and improvement of nutritional status in children attending day-care centers in Belo Horizonte, Brazil.在巴西贝洛奥里藏特的日托中心,通过在饮用水中强化铁和维生素C来减少儿童贫血并改善营养状况的效果。
Food Nutr Bull. 2011 Dec;32(4):340-6. doi: 10.1177/156482651103200405.
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Chilean complementary feeding program reduces anemia and improves iron status in children aged 11 to 18 months.智利辅食喂养计划可降低11至18个月儿童的贫血率并改善其铁营养状况。
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[Fortification of fluid milk for the prevention and treatment of iron deficiency anemia in children under 4 years of age].强化液态奶预防和治疗4岁以下儿童缺铁性贫血
Rev Saude Publica. 1996 Aug;30(4):350-7. doi: 10.1590/s0034-89101996000400008.
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Effect of fortification of drinking water with iron plus ascorbic acid or with ascorbic acid alone on hemoglobin values and anthropometric indicators in preschool children in day-care centers in Southeast Brazil.在巴西东南部日托中心,铁加抗坏血酸或单独抗坏血酸强化饮用水对学龄前儿童血红蛋白值和人体测量指标的影响。
Food Nutr Bull. 2005 Sep;26(3):259-65. doi: 10.1177/156482650502600302.
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Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula.婴儿的铁代谢:强化铁配方奶粉中牛乳铁蛋白的影响
Nutrition. 2015 Feb;31(2):304-9. doi: 10.1016/j.nut.2014.07.006. Epub 2014 Aug 1.
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The use of sugar fortified with iron tris-glycinate chelate in the prevention of iron deficiency anemia in preschool children.使用富铁三甘氨酸螯合物的糖预防学龄前儿童缺铁性贫血。
Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):54-9.
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Growth of preschool children was improved when fed an iron-fortified fermented milk beverage supplemented with Lactobacillus acidophilus.当学龄前儿童饮用添加嗜酸乳杆菌的铁强化发酵乳饮料时,其生长状况得到改善。
Nutr Res. 2008 Apr;28(4):226-32. doi: 10.1016/j.nutres.2008.02.002.
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Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age (Review).使用多种微量营养素粉对两岁以下儿童的食物进行家庭强化以促进健康和营养(综述)
Evid Based Child Health. 2013 Jan;8(1):112-201. doi: 10.1002/ebch.1895.

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