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培养的昆虫细胞与哺乳动物细胞中紫外线诱导的DNA损伤的存活与修复比较。

A comparison of survival and repair of UV-induced DNA damage in cultured insect versus mammalian cells.

作者信息

Koval T M, Hart R W, Myser W C, Hink W F

出版信息

Genetics. 1977 Nov;87(3):513-8. doi: 10.1093/genetics/87.3.513.

DOI:10.1093/genetics/87.3.513
PMID:924140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213757/
Abstract

Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the same in both cell types 4 hr after 10-50 J/m2 UV irradiations.

摘要

在培养的昆虫细胞系TN - 368和培养的哺乳动物细胞系V - 79 - 4中，测定了暴露于几种紫外线通量后的存活率和非预定DNA合成（UDS）。通过集落形成测定，TN - 368细胞对紫外线致死效应的抗性约为V - 79细胞的7倍。在10 - 50 J/m²紫外线照射4小时后，两种细胞类型中每单位DNA量的UDS量大致相同。

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本文引用的文献

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Radiat Res. 1971 Aug;47(2):426-36.
2
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Genetics. 1973 Feb;73(2):297-302. doi: 10.1093/genetics/73.2.297.
3
Hydroxyurea does not prevent synchronized G1 chinese hamster cells from entering the DNA synthetic period.羟基脲不能阻止同步化的G1期中国仓鼠细胞进入DNA合成期。
Biochem Biophys Res Commun. 1976 Mar 8;69(1):212-7. doi: 10.1016/s0006-291x(76)80294-x.