培养的昆虫细胞与哺乳动物细胞中紫外线诱导的DNA损伤的存活与修复比较。
A comparison of survival and repair of UV-induced DNA damage in cultured insect versus mammalian cells.
作者信息
Koval T M, Hart R W, Myser W C, Hink W F
出版信息
Genetics. 1977 Nov;87(3):513-8. doi: 10.1093/genetics/87.3.513.
Abstract
Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the same in both cell types 4 hr after 10-50 J/m2 UV irradiations.
摘要
在培养的昆虫细胞系TN - 368和培养的哺乳动物细胞系V - 79 - 4中，测定了暴露于几种紫外线通量后的存活率和非预定DNA合成（UDS）。通过集落形成测定，TN - 368细胞对紫外线致死效应的抗性约为V - 79细胞的7倍。在10 - 50 J/m²紫外线照射4小时后，两种细胞类型中每单位DNA量的UDS量大致相同。
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