Vogel G E
Fortschr Med. 1977 Oct 27;95(40):2437-44.
A summarized account of our experiences over 1 1/2 years is given, in relation to a minimum heparinisation technique during haemodialysis. This novel technique was made possible by the introduction of an APTT bedside method. In a comparison between the techniques employed so far for preventing a heparin-caused risk of haemorrhage and our method, the clear advantage of our method was apparent. In addition to a discussion of our methods, we describe the cases treated so far. The amounts of heparin required for dialysis are so small that a necessary coagulation can occur even in a part of the organism where there is a danger of haemorrhage. Thereby it was possible to extend the range of indication for haemodialysis substantially. By using minimum heparinisation, it is possible to perform an immediate postoperative haemodialysis. The healing of wounds, which is impaired in cases of renal insufficiency, may be improved by early dialysis without the risk of haemorrhage. Our results show that the minimum heparinisation signifies a decisive achievement in acute dialysis therapy.
本文给出了我们在一年半时间里有关血液透析期间最小肝素化技术的经验总结。这种新技术因引入了床边活化部分凝血活酶时间（APTT）检测方法而成为可能。在比较目前用于预防肝素引起的出血风险的技术与我们的方法时，我们方法的明显优势显而易见。除了讨论我们的方法外，我们还描述了迄今为止治疗的病例。透析所需的肝素量非常少，以至于即使在存在出血风险的机体部分也可能发生必要的凝血。由此，大幅扩大了血液透析的适应证范围。通过使用最小肝素化，可以在术后立即进行血液透析。早期透析可改善肾功能不全患者受损的伤口愈合，且无出血风险。我们的结果表明，最小肝素化是急性透析治疗的一项决定性成果。
