Tortolero S R, Goff D C, Nichaman M Z, Labarthe D R, Grunbaum J A, Hanis C L
Southwest Center for Prevention Research, School of Public Health, University of Texas-Houston Health Science Center, 77225, USA.
Circulation. 1997 Jul 15;96(2):418-23. doi: 10.1161/01.cir.96.2.418.
Information concerning differences in cardiovascular disease risk factors between Mexican-American and non-Hispanic white children is limited. We conducted a study to determine if there were ethnic differences in cardiovascular disease risk factors in children and whether such differences were explained by differences in body mass index.
Fasting glucose, insulin, and blood lipid concentrations, blood pressure, weight, and height were measured in a cross-sectional survey among 403 third-grade children in Corpus Christi, Tex. We found significantly higher fasting insulin and glucose concentrations among Mexican-American than among non-Hispanic white children. Mexican-American boys had slightly lower levels of HDL cholesterol and higher systolic blood pressure than non-Hispanic white boys. Ethnic differences in insulin and glucose were not explained by body mass index.
These results provide preliminary evidence that ethnic differences in insulin, glucose, body mass index, and other risk factors occur as early as age 8 to 10 years. Additional research is warranted on differences in risk factors in Mexican-American and non-Hispanic white children and the potential importance of insulin in influencing the natural history of these characteristics.
关于墨西哥裔美国儿童和非西班牙裔白人儿童心血管疾病风险因素差异的信息有限。我们开展了一项研究，以确定儿童心血管疾病风险因素是否存在种族差异，以及这些差异是否可由体重指数的差异来解释。
在得克萨斯州科珀斯克里斯蒂对403名三年级儿童进行的横断面调查中，测量了空腹血糖、胰岛素、血脂浓度、血压、体重和身高。我们发现，墨西哥裔美国儿童的空腹胰岛素和血糖浓度显著高于非西班牙裔白人儿童。墨西哥裔美国男孩的高密度脂蛋白胆固醇水平略低于非西班牙裔白人男孩，收缩压则高于他们。胰岛素和血糖的种族差异无法用体重指数来解释。
这些结果提供了初步证据，表明胰岛素、血糖、体重指数及其他风险因素的种族差异早在8至10岁时就已出现。有必要对墨西哥裔美国儿童和非西班牙裔白人儿童的风险因素差异以及胰岛素在影响这些特征自然病程方面的潜在重要性进行更多研究。
