Osadchiĭ L I, Balueva T V, Sergeev I V
Aviakosm Ekolog Med. 1997;31(3):19-23.
In acute experiments with antiorthostatic rats tilt-induced changes in the parameters of cardiac activity (left ventricle systolic pressure (LVPs), its first derivative dp/dt, end-diastolic pressure (EDP) were compared in relation to the directionality and extent of systolic (sAP) and diastolic arterial pressure (dAP) shifts. Rise of the tilt angle by 15-45 degrees reduced sAP and dAP, increased LVPs and EDP and did not influence dp/dt. Changes in the cardiac parameters and AP were not unidirectional; sAP and dAP shifts were asynchronous. In a special experimental series, higher tilt angle was found to bring about opposite changes in cardiac ejection (CE) and total peripheral resistance (TPR). Growth in CE was concurrent to a progressive decline in TPR. Discussed is the response of the vascular system to antiorthostasis the unique character of which is vasodilatation.
在对抗直立位大鼠进行的急性实验中，将倾斜诱导的心脏活动参数（左心室收缩压（LVPs）、其一阶导数dp/dt、舒张末期压力（EDP））的变化与收缩期（sAP）和舒张期动脉压（dAP）变化的方向性和程度进行了比较。倾斜角度增加15 - 45度会降低sAP和dAP，增加LVPs和EDP，且不影响dp/dt。心脏参数和动脉压的变化并非单向的；sAP和dAP的变化是不同步的。在一个特殊的实验系列中，发现更高的倾斜角度会使心脏射血（CE）和总外周阻力（TPR）产生相反的变化。CE的增加与TPR的逐渐下降同时发生。讨论了血管系统对抗直立位的反应，其独特之处在于血管舒张。
