幽门螺杆菌感染的治愈可改善胃体胃炎患者的胃酸分泌。

Cure of Helicobacter pylori infection improves gastric acid secretion in patients with corpus gastritis.

作者信息

Gutierrez O, Melo M, Segura A M, Angel A, Genta R M, Graham D Y

机构信息

Dept. of Gastroenterology, Hospital San Juan de Dios Universidad Nacional de Colombia, Bogotu, Colombia.

出版信息

Scand J Gastroenterol. 1997 Jul;32(7):664-8. doi: 10.3109/00365529708996515.

DOI:10.3109/00365529708996515

PMID:9246705

Abstract

BACKGROUND

For more than 30 years it has been known that gastric acid secretion is inversely related to the extent and severity of corpal gastritis. We therefore evaluated the effect of cure of Helicobacter pylori infection on basal and pentagastrin-stimulated acid secretion.

METHODS

Basal acid output (BAO) and maximal acid output (MAO) were assessed in 11 H. pylori-infected dyspeptic patients (8 women and 3 men; mean age, 28 years) before and after successful anti-H. pylori therapy.

RESULTS

The gastritis index was significantly lower after therapy and was associated with an increase in both BAO and MAO after cure of the H. pylori infection (BAO from 0.3 mmol/h and MAO from 4.8 mmol/h to 19 mmol/ h). Basal and stimulated acid concentrations also increased (29.1 +/- 36.6 to 54 +/- 31 mmol/l and 72.5 +/- 46 to 120.1 +/- 30 mmol/l, respectively, for basal and stimulated acid concentrations; P < 0.05 for peak and MAO, P = 0.07 for BAO).

CONCLUSION

Gastric acid secretion increased into the normal range after successful treatment of H. pylori infection, suggesting that gastric function can recover to normal or almost normal after cure of H. pylori infection.

摘要

背景

30多年来，人们已经知道胃酸分泌与胃体胃炎的范围和严重程度呈负相关。因此，我们评估了幽门螺杆菌感染治愈对基础胃酸分泌和五肽胃泌素刺激的胃酸分泌的影响。

方法

在11例幽门螺杆菌感染的消化不良患者（8名女性和3名男性；平均年龄28岁）成功进行抗幽门螺杆菌治疗前后，评估基础胃酸排出量（BAO）和最大胃酸排出量（MAO）。

结果

治疗后胃炎指数显著降低，且与幽门螺杆菌感染治愈后BAO和MAO的增加相关（BAO从0.3 mmol/h，MAO从4.8 mmol/h增加到19 mmol/h）。基础胃酸浓度和刺激后的胃酸浓度也增加（基础胃酸浓度从29.1±36.6 mmol/l增加到54±31 mmol/l，刺激后的胃酸浓度从72.5±46 mmol/l增加到120.1±30 mmol/l；峰值和MAO的P<0.05，BAO的P=0.07）。