Leidenius M H, Färkkilä M A, Kärkkäinen P, Taskinen E I, Kellokumpu I H, Höckerstedt K A
Fourth Dept. of Surgery, Helsinki University Central Hospital, Finland.
Scand J Gastroenterol. 1997 Jul;32(7):706-11. doi: 10.3109/00365529708996522.
The aim of this study was to evaluate the role of primary sclerosing cholangitis (PSC) as a cofactor in the dysplasia-carcinoma sequence in ulcerative colitis (UC).
Forty-five patients with UC and concomitant PSC and 45 pair-matched control patients with UC only were examined for colorectal dysplasia and carcinoma.
The median duration of UC was 11 years in the group with UC and PSC and 15 years in the control group. Thirteen of the 45 patients (29%) with UC and PSC had colorectal neoplasia: 4, carcinoma; 2, high-grade dysplasia; and 7, low-grade dysplasia. Four of the 45 control patients (9%) had neoplastic findings: 1, carcinoma; 1, high-grade dysplasia, and 2, low-grade dysplasia (P < 0.05).
The results suggest that the risk of colorectal dysplasia and carcinoma in patients with UC is increased by concomitant PSC.
本研究旨在评估原发性硬化性胆管炎（PSC）作为溃疡性结肠炎（UC）发育异常 - 癌序列中的一个辅助因素的作用。
对45例患有UC并伴有PSC的患者以及45例仅患有UC的配对对照患者进行了结直肠发育异常和癌的检查。
患有UC和PSC的组中UC的中位病程为11年，对照组为15年。45例患有UC和PSC的患者中有13例（29%）发生了结直肠肿瘤：4例为癌；2例为高级别发育异常；7例为低级别发育异常。45例对照患者中有4例（9%）有肿瘤性发现：1例为癌；1例为高级别发育异常，2例为低级别发育异常（P < 0.05）。
结果表明，伴有PSC会增加UC患者发生结直肠发育异常和癌的风险。
