Mehler M F, Kessler J A
Dept of Neurology, Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Trends Neurosci. 1997 Aug;20(8):357-65. doi: 10.1016/s0166-2236(96)01045-4.
It is now clear that cytokines traditionally viewed as immune modulators participate in inflammatory responses within the adult nervous system. However, in the developing nervous system hematolymphopoietic cytokines also play a role unrelated to neural-immune interactions. Instead, many of these factors subserve primary regulatory functions related both to the morphogenesis and to the cellular maturation of the central and peripheral nervous systems. This article focuses specifically on cytokine actions in neural development.
现在已经清楚，传统上被视为免疫调节剂的细胞因子参与了成人神经系统内的炎症反应。然而，在发育中的神经系统中，造血淋巴细胞因子也发挥着与神经免疫相互作用无关的作用。相反，这些因子中的许多都具有与中枢和外周神经系统的形态发生和细胞成熟相关的主要调节功能。本文特别关注细胞因子在神经发育中的作用。
