Piven J, Bailey J, Ranson B J, Arndt S
Department of Psychiatry, University of Iowa, Iowa City, USA.
Am J Psychiatry. 1997 Aug;154(8):1051-6. doi: 10.1176/ajp.154.8.1051.
The purpose of this study was to examine the size of subregions of the corpus callosum in autistic individuals.
The areas of three subregions (anterior, body, and posterior) of the corpus callosum were examined on midsagittal magnetic resonance images of 35 autistic subjects whose mean age was 18 years and 36 healthy comparison subjects matched on age and IQ.
After controlling for total brain volume, gender, and performance IQ, the authors detected a significantly smaller size of the body and posterior subregions of the corpus callosum in the autistic individuals.
In the context of recent reports of increased brain size in autism, several possible mechanisms are considered in exploring the significance of a smaller relative size of the corpus callosum in autism.
本研究旨在检测自闭症个体胼胝体各亚区的大小。
在35名平均年龄为18岁的自闭症受试者以及36名年龄和智商相匹配的健康对照受试者的矢状位磁共振图像上，检测胼胝体三个亚区（前部、体部和后部）的面积。
在控制了全脑体积、性别和操作智商后，作者发现自闭症个体胼胝体的体部和后部亚区明显较小。
鉴于近期有关自闭症患者脑容量增加的报道，在探讨自闭症患者胼胝体相对较小的意义时，考虑了几种可能的机制。
