Gelatt K N, Gum G G, Merideth R E, Bromberg N
Invest Ophthalmol Vis Sci. 1982 Jul;23(1):131-5.
Episcleral venous pressure was measured by a noninvasive method with a modified force-displacement transducer in six laboratory-quality normotensive and 12 glaucomatous beagles. The dogs were anesthetized by ketamine-xylazine, acepromazine-ketamine, and halothane. Simultaneous intraocular pressure (IOP) and blood pressure were recorded. The mean episcleral venous pressures in normotensive beagles were 11.4 to 11.6 mm Hg with the three methods of anesthesia; in the glaucomatous beagles the mean episcleral pressures were 10.6 to 12.5 mm Hg. There were no significant differences in episcleral venous pressure (p less than 0.19 and greater) and blood pressure (p less than 0.53 and greater) between the normotensive and glaucomatous beagles. IOP was significantly different between the normotensive and glaucomatous beagles anesthetized with acepromazine-ketamine (mean IOP, 23.4 and 34.2 mm Hg, respectively; p less than 0.02) and halothane (mean IOP, 19.9 and 27.4 mm Hg, respectively; p less than 0.001) but not significant with anesthesia with ketamine-xylazine (mean IOP, 26.0 and 37.8 mm Hg, respectively; p less than 0.12). Episcleral venous pressure is unchanged as the disease progresses in the glaucomatous beagle.
采用改良的力-位移换能器通过无创方法测量了6只实验室标准血压正常的比格犬和12只青光眼比格犬的巩膜静脉压。这些犬分别用氯胺酮-赛拉嗪、乙酰丙嗪-氯胺酮和氟烷麻醉。同时记录眼内压（IOP）和血压。三种麻醉方法下，血压正常的比格犬的平均巩膜静脉压为11.4至11.6毫米汞柱；青光眼比格犬的平均巩膜静脉压为10.6至12.5毫米汞柱。血压正常的比格犬和青光眼比格犬之间的巩膜静脉压（p大于0.19）和血压（p大于0.53）无显著差异。在用乙酰丙嗪-氯胺酮麻醉的血压正常的比格犬和青光眼比格犬之间（平均IOP分别为23.4和34.2毫米汞柱；p小于0.02）以及用氟烷麻醉的两者之间（平均IOP分别为19.9和27.4毫米汞柱；p小于0.001），IOP有显著差异，但在用氯胺酮-赛拉嗪麻醉时无显著差异（平均IOP分别为26.0和37.8毫米汞柱；p小于0.12）。在青光眼比格犬中，随着疾病进展，巩膜静脉压无变化。
