Gwin R M, Gelatt K N, Gum G G, Peiffer R L
Am J Vet Res. 1978 Jan;39(1):83-6.
Dipivalyl epinephrine and l-epinephrine were evaluated in various concentrations in normotensive and glaucomatous Beagles. In higher concentrations, both drugs produced significant lowering of intraocular pressure. Mydriasis and some local irritation occurred. The hypotony after drug administration tended to be greater in glaucomatous than in normotensive Beagles. The glaucomatous Beagle may be a valuable biomedical model in the investigation of various pharmacologic substances.
在正常血压和青光眼比格犬中，对不同浓度的二特戊酰肾上腺素和左旋肾上腺素进行了评估。在较高浓度下，两种药物均能显著降低眼压。出现了散瞳和一些局部刺激。给药后青光眼比格犬的低眼压往往比正常血压比格犬更明显。青光眼比格犬可能是研究各种药理物质的一种有价值的生物医学模型。
