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甲氧苄啶对伯氏疏螺旋体的体外活性。

In vitro activity of trimethoprim against Borrelia burgdorferi.

作者信息

Reisinger E C, Wendelin I, Gasser R

机构信息

Department of Medicine, Karl-Franzens University, Graz, Austria.

出版信息

Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):458-60. doi: 10.1007/BF02471911.

DOI:10.1007/BF02471911
PMID:9248750
Abstract

A new culture medium has been developed to evaluate the activity of trimethoprim and sulfamethoxazole against Borrelia burgdorferi in vitro. In this specially modified Barbour-Stoenner-Kelly medium, in which antagonizing substances were reduced to a minimum, trimethoprim was more active against Borrelia burgdorferi than against a sensitive strain of Escherichia coli, but sulfamethoxazole was not active against Borrelia burgdorferi.

摘要

一种新的培养基已被开发出来,用于在体外评估甲氧苄啶和磺胺甲恶唑对伯氏疏螺旋体的活性。在这种经过特殊改良的巴伯-斯托纳-凯利培养基中,拮抗物质被降至最低,甲氧苄啶对伯氏疏螺旋体的活性比对敏感大肠杆菌菌株的活性更高,但磺胺甲恶唑对伯氏疏螺旋体无活性。

相似文献

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In vitro activity of trimethoprim against Borrelia burgdorferi.甲氧苄啶对伯氏疏螺旋体的体外活性。
Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):458-60. doi: 10.1007/BF02471911.
2
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Trimethoprim resistance and single-agent use.
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Esterases in serum-containing growth media counteract chloramphenicol acetyltransferase activity in vitro.含血清生长培养基中的酯酶在体外可抵消氯霉素乙酰转移酶的活性。
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本文引用的文献

1
Antibiotics and increased temperature against Borrelia burgdorferi in vitro.抗生素及升温对体外伯氏疏螺旋体的作用
Scand J Infect Dis. 1996;28(2):155-7. doi: 10.3109/00365549609049067.
2
Inactivation of diaminopyrimidines and sulfonamides in Barbour-Stoenner-Kelly medium for isolation of Borrelia burgdorferi.用于分离伯氏疏螺旋体的巴伯-斯托纳-凯利培养基中二氨基嘧啶和磺胺类药物的灭活
Eur J Clin Microbiol Infect Dis. 1995 Aug;14(8):732-3. doi: 10.1007/BF01690890.
3
Standardization of medium for culturing Lyme disease spirochetes.莱姆病螺旋体培养培养基的标准化
J Clin Microbiol. 1993 May;31(5):1251-5. doi: 10.1128/jcm.31.5.1251-1255.1993.
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Evaluation of agents for use in medium for selective isolation of Lyme disease and relapsing fever Borrelia species.用于选择性分离莱姆病和回归热疏螺旋体物种的培养基中使用的试剂评估。
Eur J Clin Microbiol Infect Dis. 1993 Jul;12(7):512-8. doi: 10.1007/BF01970956.
5
Roxithromycin in the treatment of Lyme disease--update and perspectives.罗红霉素治疗莱姆病——最新进展与展望
Infection. 1995;23 Suppl 1:S39-43. doi: 10.1007/BF02464959.
6
Effects of penicillin, ceftriaxone, and doxycycline on morphology of Borrelia burgdorferi.青霉素、头孢曲松和强力霉素对伯氏疏螺旋体形态的影响。
Antimicrob Agents Chemother. 1995 May;39(5):1127-33. doi: 10.1128/AAC.39.5.1127.
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Isolation and cultivation of Lyme disease spirochetes.莱姆病螺旋体的分离与培养。
Yale J Biol Med. 1984 Jul-Aug;57(4):521-5.
8
European Borrelia burgdorferi isolated from humans and ticks culture conditions and antibiotic susceptibility.从人类和蜱虫中分离出的欧洲伯氏疏螺旋体的培养条件和抗生素敏感性。
Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Dec;263(1-2):112-8. doi: 10.1016/s0176-6724(86)80110-9.
9
Comparative antimicrobial activity of the new macrolides against Borrelia burgdorferi.
Eur J Clin Microbiol Infect Dis. 1989 Jul;8(7):651-3. doi: 10.1007/BF01968150.
10
Oral treatment of late borreliosis with roxithromycin plus co-trimoxazole.用罗红霉素加复方新诺明口服治疗晚期莱姆病。
Lancet. 1990 Dec 15;336(8729):1514. doi: 10.1016/0140-6736(90)93225-e.