Plubrukarn A, Smith D W, Cramer R E, Davidson B S
Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.
J Nat Prod. 1997 Jul;60(7):712-5. doi: 10.1021/np960673o.
A new imidazole alkaloid, (2E,9E)-pyronaamidine 9-(N-methylimine) (4), was isolated along with the known compounds pyronaamidine (3) and kealiiquinone (5) from the yellow sponge Leucetta sp. cf. chagosensis collected near the Island of Rota, Northern Mariana Islands. Single-crystal X-ray diffraction analysis allowed the unambiguous assignment of the structure of compound 4, including the position of the exchangeable proton and the geometry of the two imino double bonds. Compound 4 exhibited mild cytotoxicity toward the A-549, MCF-7, and HT-29 human tumor cell lines.
从北马里亚纳群岛罗塔岛附近采集的疑似查戈斯亮海绵（Leucetta sp. cf. chagosensis）黄色海绵中，分离出一种新的咪唑生物碱(2E,9E)-吡咯那米定9-(N-甲基亚胺)(4)，以及已知化合物吡咯那米定(3)和凯阿利醌(5)。单晶X射线衍射分析明确了化合物4的结构，包括可交换质子的位置和两个亚氨基双键的几何形状。化合物4对A-549、MCF-7和HT-29人肿瘤细胞系表现出轻微的细胞毒性。
