Gürsel G, Türktas H, Gökçora N, Tekin I O
Department of Respiratory Diseases, Gazi University School of Medicine, Ankara, Turkey.
J Asthma. 1997;34(4):313-9. doi: 10.3109/02770909709067221.
The aim of the present study was to investigate whether sputum eosinophil cationic protein (ECP) concentrations could be a useful marker in the differential diagnosis between intrinsic asthma and chronic obstructive pulmonary disease (COPD). For this purpose total blood eosinophil counts were obtained and concentrations of serum and sputum ECP from 10 nonatopic asthmatics with a mild attack and 9 COPD patients with acute exacerbation were measured by radioimmunoassay. Mean serum ECP concentration was 54.3 +/- 23.0 micrograms/L in the asthmatic group and 83.3 +/- 79.2 micrograms/L in the COPD group (p: n.s.). In the group of asthmatics mean sputum ECP level was 984.5 +/- 1245.5 micrograms/L/g sputum and in the COPD group it was 417.5 +/- 363.5 micrograms/L/g sputum. There was no significant difference in sputum ECP levels between patients with asthma and COPD. We conclude that neither sputum nor serum ECP levels are useful markers in differential diagnosis of asthma attack and acute exacerbation of COPD.
本研究的目的是调查痰液嗜酸性粒细胞阳离子蛋白（ECP）浓度是否可作为鉴别内源性哮喘和慢性阻塞性肺疾病（COPD）的有用标志物。为此，获取了10名轻度发作的非特应性哮喘患者和9名急性加重期COPD患者的全血嗜酸性粒细胞计数，并通过放射免疫测定法测量了血清和痰液ECP的浓度。哮喘组血清ECP平均浓度为54.3±23.0微克/升，COPD组为83.3±79.2微克/升（p：无显著性差异）。哮喘组痰液ECP平均水平为984.5±1245.5微克/升/克痰液，COPD组为417.5±363.5微克/升/克痰液。哮喘患者和COPD患者的痰液ECP水平无显著差异。我们得出结论，痰液和血清ECP水平均不是鉴别哮喘发作和COPD急性加重的有用标志物。
