Göke M, Hoffmann J C, Evers J, Krüger H, Manns M P
Department of Gastroenterology and Hepatology, Medzinische Hochschule Hannover, Germany.
J Gastroenterol. 1997 Aug;32(4):480-6. doi: 10.1007/BF02934086.
Adhesion molecules mediate the extravasation of leukocytes and their accumulation in inflamed tissues. In the present study, serum concentrations of the selectin (sP- and sE-selectin) and immunoglobulin supergene family (sICAM-1 and sVCAM-1) of adhesion molecules were measured in 93 patients with inflammatory bowel disease (Crohn's disease, n = 65; ulcerative colitis, n = 28) and 58 age-matched normal controls. sP-selectin serum concentrations (mean +/- SEM ng/ml) of patients with Crohn's disease (399 +/- 33 ng/ml) and ulcerative colitis (385 +/- 42 ng/ml) were increased (P = 0.0067 and P = 0.0193, respectively) compared to controls (251 +/- 33 ng/ml). In contrast, E-selectin serum levels of patients with Crohn's disease (58 +/- 5 ng/ml) and ulcerative colitis (64 +/- 12 ng/ml) were not significantly higher than those of controls (53 +/- 5 ng/ml). sICAM-1 serum concentrations of patients with Crohn's disease (420 +/- 19 ng/ml) and those with ulcerative colitis (375 +/- 40 ng/ml) were elevated (P = 0.0001 and P = 0.0473, respectively) compared to controls (297 +/- 8 ng/ml). Further, sVCAM-1 levels of patients with Crohn's disease (664 +/- 43 ng/ml) and ulcerative colitis (963 +/- 162 ng/ml) were increased (P = 0.0222 and P = 0.0121, respectively) compared to controls (510 +/- 31 ng/ml). With few exceptions, serum levels of soluble adhesion molecules were not significantly correlated to disease activity indices or disease localization. Elevated circulating selectin and immunoglobulin supergene type adhesion molecules may compete with membrane-bound forms for their cognate ligands and thereby limit the rolling and stable adhesion of leukocytes.
黏附分子介导白细胞的渗出及其在炎症组织中的聚集。在本研究中，检测了93例炎症性肠病患者（克罗恩病，n = 65；溃疡性结肠炎，n = 28）和58例年龄匹配的正常对照者血清中选择素（可溶性P选择素和可溶性E选择素）及免疫球蛋白超基因家族黏附分子（可溶性细胞间黏附分子-1和可溶性血管细胞黏附分子-1）的浓度。与对照组（251±33 ng/ml）相比，克罗恩病患者（399±33 ng/ml）和溃疡性结肠炎患者（385±42 ng/ml）的可溶性P选择素血清浓度升高（分别为P = 0.0067和P = 0.0193）。相比之下，克罗恩病患者（58±5 ng/ml）和溃疡性结肠炎患者（64±12 ng/ml）的E选择素血清水平并不显著高于对照组（53±5 ng/ml）。与对照组（297±8 ng/ml）相比，克罗恩病患者（420±19 ng/ml）和溃疡性结肠炎患者（375±40 ng/ml）的可溶性细胞间黏附分子-1血清浓度升高（分别为P = 0.0001和P = 0.0473）。此外，与对照组（510±31 ng/ml）相比，克罗恩病患者（664±43 ng/ml）和溃疡性结肠炎患者（963±162 ng/ml）的可溶性血管细胞黏附分子-1水平升高（分别为P = 0.0222和P = 0.0121）。除少数例外情况外，可溶性黏附分子的血清水平与疾病活动指数或疾病定位无显著相关性。循环中升高的选择素和免疫球蛋白超基因类型黏附分子可能与其膜结合形式竞争同源配体，从而限制白细胞的滚动和稳定黏附。
