Arroyo C M
Drug Assessment Division, US Army Medical, Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5425, USA.
Chem Biol Interact. 1997 Jul 11;105(2):119-29. doi: 10.1016/s0009-2797(97)00041-0.
While applying electron paramagnetic resonance (EPR)/Spin Trapping techniques, several reactive intermediate species were identified in the reaction of perfluoroisobutylene (PFIB) with nitrone and nitroso spin trap agents: the carbon dioxide radical anion (CO2.-), a carbonyl fluoride intermediate (COF), and vinyl carbanions of PFIB. The reaction of PFIB with N-t-butyl-alpha-phenylnitrone (PBN) forms a dipolar ion which undergoes electron transfer reactions generating stable nitrone spin adducts. Nitroso compounds reacted with carbanions derived from PFIB, which raises the possibility that electron transfer reactions of this type might account for the observed nitroxides. Our results suggest that PFIB undergoes some type of electron transfer reaction leading to several reactive intermediate species (RIS). The implications of these observations on pulmonary damage caused by inhalation of PFIB are discussed.
在应用电子顺磁共振（EPR）/自旋捕获技术时，在全氟异丁烯（PFIB）与硝酮和亚硝基自旋捕获剂的反应中鉴定出了几种反应性中间物种：二氧化碳自由基阴离子（CO2.-）、羰基氟中间体（COF）以及PFIB的乙烯基碳负离子。PFIB与N-叔丁基-α-苯基硝酮（PBN）的反应形成了一种偶极离子，该偶极离子会发生电子转移反应，生成稳定的硝酮自旋加合物。亚硝基化合物与源自PFIB的碳负离子发生反应，这增加了这种类型的电子转移反应可能是观察到的氮氧化物的原因的可能性。我们的结果表明，PFIB会发生某种类型的电子转移反应，从而导致几种反应性中间物种（RIS）的产生。讨论了这些观察结果对吸入PFIB所导致的肺部损伤的影响。
