Van Goozen S H, Wiegant V M, Endert E, Helmond F A, Van de Poll N E
Department of Child and Adolescent Psychiatry, University Hospital Utrecht, The Netherlands.
Arch Sex Behav. 1997 Aug;26(4):359-82. doi: 10.1023/a:1024587217927.
The role of sex hormones in sexuality and mood across the menstrual cycle was investigated. Twenty-one normal health women were followed for one menstrual cycle. Blood samples were taken frequently, and analyzed for estradiol, progesterone, testosterone, androstenedione, dehydroepiandrosterone sulfate, cortisol, and sex hormone-binding globulin. A diary concerning sexual interest and behavior, and different moods, was completed daily. Although the sample was not large, a clear effect of menstrual cycle phase on levels of testosterone and the free testosterone index was demonstrated. In a preliminary screening interview, 11 of the 21 women had reported that they suffered from premenstrual complaints (PC), the other 10 had reported no complaints in the premenstrual phase (NPC). Significant differences between the two groups were established in estradiol and the estradiol-progesterone ratio, with the NPC group having higher levels of both endocrine parameters across different menstrual samples. Psychologically, a cycle effect on tension and sexual interest was demonstrated. The NPC group reported a peak in sexual interest in the premenstrual phase, whereas the PC group reported a peak in the ovulatory phase. There was a difference between the two groups in feelings of fatigue but not in other moods across the menstrual cycle. The study provides further evidence of the importance of androgen levels in women's sexuality and shows again that the relationship between menstrual cycle phase and sexuality is much clearer than between phase and mood.
研究了性激素在整个月经周期中性欲和情绪方面的作用。对21名健康正常的女性进行了一个月经周期的跟踪。频繁采集血样，并分析其中的雌二醇、孕酮、睾酮、雄烯二酮、硫酸脱氢表雄酮、皮质醇和性激素结合球蛋白。要求她们每天填写一份关于性兴趣和行为以及不同情绪的日记。尽管样本量不大，但月经周期阶段对睾酮水平和游离睾酮指数的显著影响得到了证实。在初步筛查访谈中，21名女性中有11名报告称她们有经前不适（PC），另外10名报告在经前期没有不适（NPC）。两组在雌二醇和雌二醇 - 孕酮比值方面存在显著差异，在不同月经样本中，NPC组的这两个内分泌参数水平都更高。在心理方面，证实了月经周期对紧张情绪和性兴趣有影响。NPC组报告在经前期性兴趣达到峰值，而PC组报告在排卵期达到峰值。在整个月经周期中，两组在疲劳感方面存在差异，但在其他情绪方面没有差异。该研究进一步证明了雄激素水平在女性性欲中的重要性，并再次表明月经周期阶段与性欲之间的关系比与情绪之间的关系更为明确。
