Andersson J L, Muhr C, Lilja A, Valind S, Lundberg P O, Långström B
Uppsala University PET Centre, Sweden.
Cephalalgia. 1997 Aug;17(5):570-9. doi: 10.1046/j.1468-2982.1997.1705570.x.
Eleven cases of migraine with and without aura were investigated with positron emission tomography (PET). Regional cerebral blood flow (rCBF), oxygen metabolism (rCMRO2) and oxygen extraction (rOER) were measured during baseline (n = 11), aura (n = 6), headache (n = 10) and after treatment with sumatriptan (n = 4). Data were analysed using an ROI-based approach from 26 different anatomically defined regions, and also an exploratory approach whereby all subjects were normalized to a stereotactic brain atlas; t-maps were constructed by depicting significant changes between states. The exploratory approach revealed a region corresponding to the primary visual cortex with significant reductions in rCBF (23.1%) and rCMRO2 (22.5%), but no change in rOER during the headache phase compared to baseline. These data suggest that cerebral ischemia was not the primary cause of the attacks in these cases.
采用正电子发射断层扫描（PET）对11例有先兆和无先兆偏头痛患者进行了研究。在基线期（n = 11）、先兆期（n = 6）、头痛期（n = 10）以及舒马曲坦治疗后（n = 4）测量了局部脑血流量（rCBF）、氧代谢（rCMRO2）和氧摄取率（rOER）。数据采用基于感兴趣区（ROI）的方法进行分析，该方法来自26个不同的解剖学定义区域，同时还采用了一种探索性方法，即将所有受试者归一化到一个立体定向脑图谱；通过描绘不同状态之间的显著变化构建t图。探索性方法显示，与基线相比，在头痛期，对应于初级视觉皮层的一个区域rCBF显著降低（23.1%），rCMRO2显著降低（22.5%），但rOER无变化。这些数据表明，在这些病例中，脑缺血不是发作的主要原因。
